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Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
Upadhyay, Jyoti; Rana, Mahendra; Bisht, Satpal Singh; Rana, Amita; Durgapal, Sumit; Juyal, Vijay.
Afiliação
  • Upadhyay, Jyoti; Kumaun University. Department of Pharmaceutical Sciences. Nainital. IN
  • Rana, Mahendra; Kumaun University. Department of Pharmaceutical Sciences. Nainital. IN
  • Bisht, Satpal Singh; Kumaun University. Department of Zoology. D. S. B. Campus. Nainital. IN
  • Rana, Amita; Kumaun University. Department of Pharmaceutical Sciences. Nainital. IN
  • Durgapal, Sumit; Kumaun University. Department of Pharmaceutical Sciences. Nainital. IN
  • Juyal, Vijay; Kumaun University. Department of Pharmaceutical Sciences. Nainital. IN
Braz. J. Pharm. Sci. (Online) ; 55: e18194, 2019. tab, graf, ilus
Artigo em Inglês | LILACS | ID: biblio-1011639
Biblioteca responsável: BR40.1
Localização: BR40.1
ABSTRACT
Experiments were conducted to investigate the effects on health of pregnant female rats exposed to pesticides glyphosate and carbendazim. Glyphosate is used as herbicide and carbendazim as a fungicide; all are commercially available readily for various agricultural and domestic purposes. The hypothesis tested in this investigation is that pesticide exposure during pregnancy causes changes in biomarker responses like serum glucose level, total protein, total cholesterol, triglycerides, SGOT, SGPT, and billirubin level. Significant changes were observed in all above biomarker responses, when compared with the reference. Histopathology of skin and kidney of rat neonates showed marked damage. Degenerative changes and vacuolization with eroded capsule were observed in kidney sample and thinning of epidermis in skin sample was seen in pesticides exposed neonates of rats. The serum biochemistry and histopathological findings are valuable markers for observing the changes caused by pesticide exposure.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Recém-Nascido / Biomarcadores / Exposição a Praguicidas Limite: Animais Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Kumaun University/IN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Recém-Nascido / Biomarcadores / Exposição a Praguicidas Limite: Animais Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Kumaun University/IN
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