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Prognostic significance of inflammation-based prognostic scoring in patients with upper urinary tract urothelial carcinoma
Int. braz. j. urol; 45(3): 541-548, May-June 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-1012322
Biblioteca responsável: BR1.1
ABSTRACT

ABSTRACT OBJECTIVES:

To investigate whether Glasgow Prognostic Score has prognostic significance in patients with upper urinary urothelial carcinoma.

PATIENTS AND METHODS:

We retrospectively reviewed the clinical records of 74 patients with upper urinary urothelial carcinoma. We set the cut-off value for C-reactive protein as 1.0mg/dL, and 3.5mg/dL for albumin as Glasgow Prognostic Score. Their blood data including albumin and C-reactive protein for Glasgow Prognostic Score and cytokeratin 19 fragment 21-1 as a tumor marker were measured before starting treatment. The patients were stratified into three groups with Glasgow Prognostic Score: The Group-1, albumin ≥3.5g/dL and C-reactive protein < 1.0mg/dL; Group-2, albumin < 3.5g/dL or C-reactive protein ≥1.0mg/dL; Group-3, albumin < 3.5g/dL and C-reactive protein ≥1.0mg/dL.

RESULTS:

The median follow-up for all patients was 26.9 months (range: 10.9-91.1 months), during which 37 (50%) patients died. There was a significant difference in the estimated survival rate among the 3 groups stratified by Glasgow Prognostic Score. The estimated survival rate in the Group-1 was significantly higher than those in Groups 2 and 3. In the univariate analysis C-reactive protein, serum cytokeratin 19 fragment 21-1 and Glasgow Prognostic Score were significant predictors of overall survival. On the multivariate analysis, serum cytokeratin 19 fragment 21-1 and Glasgow Prognostic Score were independently associated with shorter overall survival.

CONCLUSION:

Our review suggests Glasgow Prognostic Score may play as a prognostic predictor for upper urinary urothelial carcinoma.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Aspecto clínico: Predição / Prognóstico Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Japão Instituição/País de afiliação: Sanaikai General Hospital/JP / Toho University Omori Medical Center/JP