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Head and neck manifestations of granulomatosis with polyangiitis: a retrospective analysis of 19 patients and review of the literature
Carnevale, Claudio; Arancibia-Tagle, Diego; Sarría-Echegaray, Pedro; Til-Pérez, Guillermo; Tomás-Barberán, Manuel.
Afiliação
  • Carnevale, Claudio; Department of Otorhinolaryngology, Hospital Universitari Son Espases. Palma de Mallorca. ES
  • Arancibia-Tagle, Diego; Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Son Espases. Palma de Mallorca. ES
  • Sarría-Echegaray, Pedro; Department of Otorhinolaryngology, Hospital Universitari Son Espases. Palma de Mallorca. ES
  • Til-Pérez, Guillermo; Department of Otorhinolaryngology, Hospital Universitari Son Espases. Palma de Mallorca. ES
  • Tomás-Barberán, Manuel; Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Son Espases. Palma de Mallorca. ES
Int. arch. otorhinolaryngol. (Impr.) ; 23(2): 165-171, 2019. ilus
Artigo em Inglês | LILACS | ID: biblio-1015114
Biblioteca responsável: BR66.1
ABSTRACT

Introduction:

Granulomatosis with Polyangiitis (GPA) is a small vessel vasculitis characterized by a necrositing granulomatous inflammation of the upper and lower respiratory tracts and focal/proliferative glomerulonephritis. In more than 70% of the cases, the presenting symptoms are head and neck manifestations that are often misdiagnosed as infectious or allergic in etiology.

Objective:

The present study provides an analysis of head and neckmanifestations in a series of patients diagnosed with GPA. It also evaluates their medical and surgical treatment and provides a review of the relevant literature.

Methods:

A retrospective analysis of 19 patients diagnosed with GPA at a public tertiary care hospital between 2006 and 2017 was performed.

Results:

A total of 19 patients were included in the present study, and 16 of them presented head and neck manifestations. Sinonasal symptoms were the most common, affecting 56% of the patients, followed by laryngotracheal (31.25%) and ear (25%) symptoms. In 7 patients, sinonasal symptoms were the first manifestation of the disease (43.75%). Four patients underwent surgery at some stage of the disease.

Conclusions:

Head and neck involvement is common in GPA and may stand for the first or the onlymanifestation of the disease. The otolaryngologists play a central role in the diagnosis and long-term treatment of these patients, and they have to keep this pathology in mind when treating patients with ENT symptoms that do not respond as expected to the treatment (AU)
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Otorrinolaringopatias / Granulomatose com Poliangiite Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Feminino / Humanos / Masculino País/Região como assunto: Europa Idioma: Inglês Revista: Int. arch. otorhinolaryngol. (Impr.) Assunto da revista: Otorrinolaringologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Espanha Instituição/País de afiliação: Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Son Espases/ES / Department of Otorhinolaryngology, Hospital Universitari Son Espases/ES

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Otorrinolaringopatias / Granulomatose com Poliangiite Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Feminino / Humanos / Masculino País/Região como assunto: Europa Idioma: Inglês Revista: Int. arch. otorhinolaryngol. (Impr.) Assunto da revista: Otorrinolaringologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Espanha Instituição/País de afiliação: Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Son Espases/ES / Department of Otorhinolaryngology, Hospital Universitari Son Espases/ES
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