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Nyctinomops laticaudatus bat-associated rabies virus causes disease with a shorter clinical period and has lower pathogenic potential than strains isolated from wild canids
Fuoco, Natalia Langenfeld; Fernandes, Elaine Raniero; Guedes, Fernanda; Silva, Sandriana dos Ramos; Guimarães, Leticia Patricia; Silva, Nayara Ugeda; Ribeiro, Orlando Garcia; Katz, Iana Suly Santos.
Afiliação
  • Fernandes, Elaine Raniero; Pasteur Institute. São Paulo. BR
  • Guedes, Fernanda; Pasteur Institute. São Paulo. BR
  • Silva, Sandriana dos Ramos; Pasteur Institute. São Paulo. BR
  • Katz, Iana Suly Santos; Pasteur Institute. São Paulo. BR
Arch Virol ; 164(10): 2469-2477, out. 2019.
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IPPROD, Sec. Est. Saúde SP | ID: biblio-1016447
Biblioteca responsável: BR84.1
Localização: BR84.1
ABSTRACT
Rabies is a lethal viral disease that can affect a wide range of mammals. Currently, Rabies virus (RABV) in some European and American countries is maintained primarily in wild species. The regulation of viral replication is one of the critical mechanisms involved in RABV pathogenesis. However, the relationship between replication and the pathogenesis of RABV isolated from wild animals remains poorly understood. In the present study, we evaluated the pathogenicity of the street viruses Nyctinomops laticaudatus bat-associated RABV (NYBRV) and Cerdocyon thous canid-associated RABV (CECRV). Infection of mice with NYBRV led to 33% mortality with rapid disease evolution and marked histopathological changes in the CNS. In contrast, infection with CECRV led to 67% mortality and caused mild neuropathological lesions. The proportion of RABV antigen was significantly higher in the cytoplasm of neuronal cells of the cerebral cortex and in the meninges of mice infected with CECRV and NYBRV, respectively. Moreover, the replication rate of NYBRV was significantly higher (p < 0.001) than that of CECRV in neuroblastoma cells. However, CECRV replicated to a significantly higher titer in epithelial cells. Our results indicate that NYBRV infection results in rapid disease progression accompanied by frequent and intense histopathological alterations in the CNS in mice, and in a high replication rate in neuroblastoma cells. Although, CECRV is more pathogenic in mice, it caused milder histopathological changes in the CNS and replicated more efficiently in epithelial cells. Our data point to a correlation between clinical aspects of disease and the replication of RABV in different cell lines. (AU)
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Brasil Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Doenças Negligenciadas / Zoonoses Base de dados: Sec. Est. Saúde SP / SESSP-IPPROD Assunto principal: Vírus da Raiva / Replicação Viral Tipo de estudo: Estudo de etiologia / Fatores de risco Limite: Animais Idioma: Inglês Revista: Arch Virol Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Pasteur Institute/BR

Texto completo: Disponível Coleções: Bases de dados nacionais / Brasil Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Doenças Negligenciadas / Zoonoses Base de dados: Sec. Est. Saúde SP / SESSP-IPPROD Assunto principal: Vírus da Raiva / Replicação Viral Tipo de estudo: Estudo de etiologia / Fatores de risco Limite: Animais Idioma: Inglês Revista: Arch Virol Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Pasteur Institute/BR
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