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Efficacy and tolerability of mirabegron in female patients with overactive bladder symptoms after surgical treatment for stress urinary incontinence
Özkidik, Mete; Coskun, Alper; Asutay, Mehmet Kazim; Bahçeci, Tuncer; Hamidi, Nurullah.
Afiliação
  • Özkidik, Mete; Sanliurfa Research and Training Hospital. Clinic of Urology. Sanliurfa. TR
  • Coskun, Alper; Sanliurfa Research and Training Hospital. Clinic of Urology. Sanliurfa. TR
  • Asutay, Mehmet Kazim; Sanliurfa Research and Training Hospital. Clinic of Urology. Sanliurfa. TR
  • Bahçeci, Tuncer; Sanliurfa Research and Training Hospital. Clinic of Urology. Sanliurfa. TR
  • Hamidi, Nurullah; Ankara Atatürk Training and Research Hospital. Department of Urology. Ankara. TR
Int. braz. j. urol ; 45(4): 782-789, July-Aug. 2019. tab
Artigo em Inglês | LILACS | ID: biblio-1019895
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT Purpose To evaluate the efficacy and tolerability of mirabegron in females with overactive bladder (OAB) symptoms after surgical treatment for stress urinary incontinence (SUI). Materials and Methods The study was conducted with a prospective, randomized and double-blinded design. 62 patients over the age of 40 who met the inclusion-exclusion criterias of the study were enrolled and randomly divided into two groups as Group A (mirabegron 50mg) and B (solifenacin 5mg). Patients were compared based on efficacy of treatment [Patient Perception of Bladder Condition (PPBC) scale and micturition diaries], safety of treatment (heart rate, systolic and diastolic blood pressure, adverse events), number of micturitions per day, patient's satisfaction status after treatment [Visual Analog Scale(VAS)] and quality of life. Results The mean age of the population was 48.2±3.8 years and the duration of OAB symptoms was 5.9±2.9 months. Baseline values for the mean number of micturitions, volume voided in each micturition, nocturia episodes, urgency and urgency incontinence episodes were 15.3±0.34, 128±3.88mL, 3.96±1.67, 5.72±1.35 and 4.22±0.69, respectively. After treatment, values for these parameters were 11.7±0.29, 164.7±2.9mL, 2.25±0.6, 3.38±0.71, 2.31±0.49 respectively. Quality of life score, symptom bother score, VAS for treatment satisfaction score, PPBC score after treatment were 66.1±0.85, 43.7±0.77, 4.78±0.14, 4.78±0.14, respectively. There were no significant differences between two groups on any parameter. However, mirabegron showed better tolerability than solifenacin, particularly after 6 months. Conclusion Mirabegron is safe, effective and tolerable in the long-term treatment of females with OAB symptoms after surgery for stress urinary incontinence.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Tiazóis / Incontinência Urinária por Estresse / Bexiga Urinária Hiperativa / Agonistas de Receptores Adrenérgicos beta 3 / Acetanilidas Tipo de estudo: Ensaio clínico controlado / Estudo diagnóstico / Estudo observacional Aspecto: Preferência do paciente Limite: Adulto / Feminino / Humanos Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Ankara Atatürk Training and Research Hospital/TR / Sanliurfa Research and Training Hospital/TR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Tiazóis / Incontinência Urinária por Estresse / Bexiga Urinária Hiperativa / Agonistas de Receptores Adrenérgicos beta 3 / Acetanilidas Tipo de estudo: Ensaio clínico controlado / Estudo diagnóstico / Estudo observacional Aspecto: Preferência do paciente Limite: Adulto / Feminino / Humanos Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Ankara Atatürk Training and Research Hospital/TR / Sanliurfa Research and Training Hospital/TR
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