The effect of Niclosamide in acetic acid induce colitis: an experimental study
Prensa méd. argent
; 105(5): 309-316, jun 2019. tab, fig
Artigo
em Inglês
| BINACIS, LILACS
| ID: biblio-1024643
Biblioteca responsável:
AR392.1
ABSTRACT
Ulcerative colitis is an idiopathic chronic inflammatory disease of the colon for which a lot of treatment modalities are present. However, significant side effects are associated with them, and there is a need for a search for other tretment options. This study was aimed to assess the contribution of niclosamide in experimentally established colitis in rats. Animals were categorized into 5 groups; the control group undergoes no induction of UC, colitis group in which UC was induced, and animals receive no treatment, the niclosamide group that received niclosamide and sulfasalazine group that received sulfasalazine. Each group was composed of 10 animals. After the completion of a one-month period of the experiment animals were sacrificed and the following meausres were done the weight of the colon, determination of the area of mucosal damage by mm2, histological scoring after hematoxylin and eosin stain together with MAC score and immunohistochemistry of IL-6, TNF-alpha, MPO, MDA, CD62, and ICAM1. The results of the current study revealed that Nicosamide was able to reduce the area of mucosal damage, colon weight, histological and Mac scores and immunohistochemical scores of inflammatory and oxidative markers, significantly when contrasted to a group of colitis (P< 0.05). It has been concluded that Niclosamide was proved to have a significant effect as an adjuvant mode of therapy for colitis through its, anti-inflamatory and anti-oxidant effects (AU)
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
BINACIS
/
LILACS
Assunto principal:
Sulfassalazina
/
Colite Ulcerativa
/
Avaliação de Resultado de Intervenções Terapêuticas
/
Tempo para o Tratamento
/
Efeito Rebote
/
Abate de Animais
/
Niclosamida
Limite:
Animais
Idioma:
Inglês
Revista:
Prensa méd. argent
Assunto da revista:
Medicina
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Iraque
Instituição/País de afiliação:
Al-Mustansiriya University/IQ
/
Al-Nahrain University/IQ
/
University of Bahgdad/IQ