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Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions: an optical coherence tomography analysis
Ozaki, Yuichi; Garcia-Garcia, Hector M; Hideo Kajita, Alexandre; Kuku, Kayode O; Haude, Michael; Ince, Huseyin; Abizaid, Alexandre; Tölg, Ralph; Lemos, Pedro Alves; Von-Birgelen, Clemens; Christiansen, Evald Hoj; Wijns, William; Escaned, Javier; Dijkstra, Jougue; Waksman, Ron.
Afiliação
  • Ozaki, Yuichi; MedStar Washington Hospital Center. MedStar Cardiovascular Research Network. Washington. US
  • Garcia-Garcia, Hector M; MedStar Washington Hospital Center. MedStar Cardiovascular Research Network. Washington. US
  • Hideo Kajita, Alexandre; MedStar Washington Hospital Center. MedStar Cardiovascular Research Network. Washington. US
  • Kuku, Kayode O; MedStar Cardiovascular Research Network. Washington. US
  • Haude, Michael; Rheinland Klinikum Neuss GmbH Lukaskrankenhaus. Neuss. DE
  • Ince, Huseyin; Department of Cardiology Vivantes Klinikum im Friedrichschain and Am Urban. Berlim. DE
  • Abizaid, Alexandre; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Tölg, Ralph; Herzzentrum Segeberger Kliniken GmbH. Bad Segeberg. DE
  • Lemos, Pedro Alves; Instituto do Coração HCFMUSP. Universidade de São Paulo. São Paulo. BR
  • Von-Birgelen, Clemens; Department of Cardiology Medisch Spectrum Twente. Enschede. NL
  • Christiansen, Evald Hoj; Department of Cardiology, Aarhus University Hospital. Arhus. DK
  • Wijns, William; Cardiology Department, Cardiovascular Research Center Aalst OLV Hospital. Aalst. BE
  • Escaned, Javier; Section of Interventional Cardiology, MedStar Washington Hospital Center. Washington. US
  • Dijkstra, Jougue; MedStar Washington Hospital Center. MedStar Cardiovascular Research Network. Washington. US
  • Waksman, Ron; MedStar Washington Hospital Center. Washington. US
Eur Heart J Cardiovasc Imaging ; 20(8): 916-924, Ago. 2019. tabela, gráfico, ilustração
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1024905
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT

AIMS:

Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is an alternative novel device for treating coronary lesions. However, the relationship between in-scaffold dimensions after implantation of DREAMS 2G and vessel healing and luminal results at follow-up is unknown. The aim of this study is, therefore, to investigate whether the expansion index after implantation of DREAMS 2G as assessed by optical coherence tomography (OCT) impacts late luminal status and healing of the vessel wall. METHODS AND

RESULTS:

This study comprises of a total 65 out of 123 patients who were enrolled in the BIOSOLVE-II trial. We assessed both qualitative and quantitative OCT findings and the expansion index of DREAMS 2G after implantation frame by frame using OCT. Expansion index was defined as minimum scaffold area/mean reference lumen area. The over-expansion group was also defined with expansion index >1.0. The total number of analyzed frames at post-procedure and 6-month follow-up was 8243 and 8263 frames, respectively. At 6-month follow-up, in-scaffold healing was documented by the reduction of 82% in dissections, 93% in attached intra-luminal mass (ILM), 65% in non-attached ILM, and 76% in jailed side branch. The over-expansion group had significantly greater in-scaffold luminal volume loss (LVL) compared with the non-over-expansion group [over-expansion 35.0 (18.5-52.1) mm3 vs. non-over-expansion 21.0 (11.6-37.9) mm3, P = 0.039].

CONCLUSION:

Excellent in vivo healing process after implantation of DREAMS 2G was observed at 6 months. We found that higher expansion indices were associated with higher in-scaffold LVL at 6 months assessed by OCT. (AU)
Assuntos
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Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Vasos Coronários / Tomografia de Coerência Óptica / Stents Farmacológicos Tipo de estudo: Pesquisa qualitativa Idioma: Inglês Revista: Eur Heart J Cardiovasc Imaging Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Cardiology Department, Cardiovascular Research Center Aalst OLV Hospital/BE / Department of Cardiology Medisch Spectrum Twente/NL / Department of Cardiology Vivantes Klinikum im Friedrichschain and Am Urban/DE / Department of Cardiology, Aarhus University Hospital/DK / Herzzentrum Segeberger Kliniken GmbH/DE / Instituto Dante Pazzanese de Cardiologia/BR / Instituto do Coração HCFMUSP/BR / MedStar Cardiovascular Research Network/US / MedStar Washington Hospital Center/US / Rheinland Klinikum Neuss GmbH Lukaskrankenhaus/DE
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Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Vasos Coronários / Tomografia de Coerência Óptica / Stents Farmacológicos Tipo de estudo: Pesquisa qualitativa Idioma: Inglês Revista: Eur Heart J Cardiovasc Imaging Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Cardiology Department, Cardiovascular Research Center Aalst OLV Hospital/BE / Department of Cardiology Medisch Spectrum Twente/NL / Department of Cardiology Vivantes Klinikum im Friedrichschain and Am Urban/DE / Department of Cardiology, Aarhus University Hospital/DK / Herzzentrum Segeberger Kliniken GmbH/DE / Instituto Dante Pazzanese de Cardiologia/BR / Instituto do Coração HCFMUSP/BR / MedStar Cardiovascular Research Network/US / MedStar Washington Hospital Center/US / Rheinland Klinikum Neuss GmbH Lukaskrankenhaus/DE
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