Botulinum toxin as a treatment for short bowel syndrome in rats
Acta cir. bras
; 34(7): e201900705, 2019. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1038115
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
The denervation of the intestine with benzalkonium chloride (BAC) reduces mortality and improves weight gain in rats with short bowel syndrome (SBS). Nevertheless, translating these promising findings from bench to bedside is not feasible because BAC promotes peritonitis and irreversible denervation which may be followed by an uncontrolled dilatation of the viscera. The use of botulinum toxin (BT) instead of BAC to achieve the denervation of the remaining small intestine in SBS could be an interesting option because it leads to a mild and transient denervation of the intestine.Methods:
Here we evaluated the effects of the ileal denervation with BT in rats with SBS by verifying the body weight variation and intestinal morphological parameters. Four groups with 6 animals each were submitted to enterectomy with an ileal injection of saline (group E) or BT (group EBT). Control groups were submitted to simulated surgery with an ileal injection of BT (group BT) or saline (group C - control).Results:
We observed that the treatment of the remaining ileum with BT completely reversed the weight loss associated to extensive small bowel resection.Conclusion:
This may provide a new promising approach to the surgical treatment of SBS.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Obesidade
Base de dados:
LILACS
Assunto principal:
Síndrome do Intestino Curto
/
Toxinas Botulínicas
/
Denervação
/
Íleo
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
UNESP/BR
/
USP/BR
/
Universidade Estadual Paulista/BR
/
Universidade de São Paulo/BR