Vitiligo patients show significant up-regulation of aryl hydrocarbon receptor transcription factor
An. bras. dermatol
; 93(2): 302-303, Mar.-Apr. 2018. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1038265
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract IL-22 has been implicated in the pathogenesis of vitiligo. However, the role of aryl hydrocarbon receptor transcription factor that acts as a master regulator of IL-22-producing Th22 cells is not fully understood. The goal of this study was to investigate the expression pattern of aryl hydrocarbon receptor in peripheral blood mononuclear cells of patients with vitiligo and in normal controls. Transcript levels were determined by a reverse transcription quantitative real-time polymerase chain reaction. Aryl hydrocarbon receptor mRNA expression was drastically increased in patients with vitiligo compared to healthy controls (P = 0.000). Th22 cells may contribute to abnormal immune responses underlying vitiligo.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Vitiligo
/
Regulação para Cima
/
Receptores de Hidrocarboneto Arílico
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Irã
Instituição/País de afiliação:
National Institute of Genetic Engineering and Biotechnology Tehran/IR
/
Tehran University of Medical Sciences/IR