Intermittent theta-burst transcranial magnetic stimulation for autism spectrum disorder: an open-label pilot study
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 40(3): 309-311, July-Sept. 2018. tab
Artigo
em Inglês
| LILACS
| ID: biblio-1039087
Biblioteca responsável:
BR1.1
ABSTRACT
Objective:
Theta-burst stimulation (TBS) modulates synaptic plasticity more efficiently than standard repetitive transcranial magnetic stimulation delivery and may be a promising modality for neuropsychiatric disorders such as autism spectrum disorder (ASD). At present there are few effective interventions for prefrontal cortex dysfunction in ASD. We report on an open-label, pilot study of intermittent TBS (iTBS) to target executive function deficits and restricted, repetitive behaviors in male children and adolescents with ASD.Methods:
Ten right-handed, male participants, aged 9-17 years with ASD were enrolled in an open-label trial of iTBS treatment. Fifteen sessions of neuronavigated iTBS at 100% motor threshold targeting the right dorsolateral prefrontal cortex were delivered over 3 weeks.Results:
Parent report scores on the Repetitive Behavior Scale Revised and the Yale-Brown Obsessive Compulsive Scale demonstrated improvements with iTBS treatment. Participants demonstrated improvements in perseverative errors on the Wisconsin Card Sorting Test and total time for the Stroop test. The iTBS treatments were well tolerated with no serious adverse effects.Conclusion:
These preliminary results suggest that further controlled interventional studies of iTBS for ASD are warranted.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.8 Atingir a cobertura universal de saúde
Problema de saúde:
Arranjos de Entrega
Base de dados:
LILACS
Assunto principal:
Ritmo Teta
/
Estimulação Magnética Transcraniana
/
Transtorno do Espectro Autista
Limite:
Adolescente
/
Criança
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
Mayo Clinic Collage of Medicine/US
/
Universidade de São Paulo/BR