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Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries
Dehghan, Mahshid; Mente, Andrew; Rangarajan, Sumathy; Mohan, Viswanathan; Lear, Scott; Swaminathan, Sumathi; Wielgosz, Andreas; Seron, Pamela; Avezum, Alvaro; Lopez-Jaramillo, Patricio; Turbide, Ginette; Chifamba, Jephat; AlHabib, Khalid F; Mohammadifard, Noushin; Szuba, Andrzej; Khatib, Rasha; Altuntas, Yuksel; Liu, Xiaoyun; Iqbal, Romaina; Rosengren, Annika; Yusuf, Rita; Smuts, Marius; Yusufali, AfzalHussein; Li, Ning; Diaz, Rafael; Yusoff, Khalid; Kaur, Manmeet; Soman, Biju; Ismail, Noorhassim; Gupta, Rajeev; Dans, Antonio Filipinas; Sheridan, Patrick; Teo, Koon; Anand, Sonia S; Yusuf, Salim.
Afiliação
  • Dehghan, Mahshid; McMaster University. Ontario. CA
  • Mente, Andrew; McMaster University. Ontario. CA
  • Rangarajan, Sumathy; McMaster University. Ontario. CA
  • Mohan, Viswanathan; Mohan's Diabetes Specialities Centre. Chennai. IN
  • Lear, Scott; Simon Fraser University. Burnaby. CA
  • Swaminathan, Sumathi; St John's Research Institute. Bangalore. IN
  • Wielgosz, Andreas; University of Ottawa. Ottawa. CA
  • Seron, Pamela; University of La Frontera. Temuco. CL
  • Avezum, Alvaro; Dante Pazzanese Institute of Cardiology. São Paulo. BR
  • Lopez-Jaramillo, Patricio; University of Santander. Bucaramanga. CO
  • Turbide, Ginette; Laval University. Quebec. CA
  • Chifamba, Jephat; University of Zimbabwe College Of Health Sciences. Harare. ZW
  • AlHabib, Khalid F; King Saud University. Riade. SA
  • Mohammadifard, Noushin; Isfahan University of Medical Sciences. Isfahan. IR
  • Szuba, Andrzej; Wroclaw Medical University. 4th Military Hospital in Wroclaw. Breslávia. PL
  • Khatib, Rasha; Birzeit University. Cisjordânia. SA
  • Altuntas, Yuksel; University of Health Sciences. Istanbul. TR
  • Liu, Xiaoyun; Fuwai Hospital. Beijing. CN
  • Iqbal, Romaina; Aga Khan University. Karachi. PK
  • Rosengren, Annika; Sahlgrenska University Hospital. Gotemburgo. SE
  • Yusuf, Rita; Independent University Dhaka. Bangladesh. IN
  • Smuts, Marius; North-West University. Potchefstroom. ZA
  • Yusufali, AfzalHussein; Dubai Medical University. Dubai. AE
  • Li, Ning; Qingshan Lake Community Health Service Center. Nanchang. CN
  • Diaz, Rafael; Clinical Studies Latin America. Rosario. AR
  • Yusoff, Khalid; Universiti Teknologi MARA UCSI University. Sungai Buloh. MY
  • Kaur, Manmeet; School of Public Health. Chandigarh. IN
  • Soman, Biju; Health Action by People. Sree Chitra Tirunal Institute for Medical Sciences & Technology. Thiruvananthapuram. IN
  • Ismail, Noorhassim; University Kebangsaan Malaysia Medical Centre. Kuala Lumpur. MY
  • Gupta, Rajeev; Eternal Heart Care Centre & Research Institute. Jaipur. IN
  • Dans, Antonio Filipinas; University of the Philippines. Manila. PH
  • Sheridan, Patrick; McMaster University. Ontario. CA
  • Teo, Koon; McMaster University. Ontario. CA
  • Anand, Sonia S; McMaster University. Ontario. CA
  • Yusuf, Salim; McMaster University. Ontario. CA
Am. j. clin. nutr ; 111(4): 795-803, abr., 2020. tab.
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1051700
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT

BACKGROUND:

Eggs are a rich source of essential nutrients, but they are also a source of dietary cholesterol. Therefore, some guidelines recommend limiting egg consumption. However, there is contradictory evidence on the impact of eggs on diseases, largely based on studies conducted in high-income countries.

OBJECTIVES:

Our aim was to assess the association of egg consumption with blood lipids, cardiovascular disease (CVD), and mortality in large global studies involving populations from low-, middle-, and high-income countries.

METHODS:

We studied 146,011 individuals from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study. Egg consumption was recorded using country-specific validated FFQs. We also studied 31,544 patients with vascular disease in 2 multinational prospective studies ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global End Point Trial) and TRANSCEND (Telmisartan Randomized Assessment Study in ACEI Intolerant Subjects with Cardiovascular Disease). We calculated HRs using multivariable Cox frailty models with random intercepts to account for clustering by study center separately within each study.

RESULTS:

In the PURE study, we recorded 14,700 composite events (8932 deaths and 8477 CVD events). In the PURE study, after excluding those with history of CVD, higher intake of egg (≥7 egg/wk compared with <1 egg/wk intake) was not significantly associated with blood lipids, composite outcome (HR 0.96; 95% CI 0.89, 1.04; P-trend = 0.74), total mortality (HR 1.04; 95% CI 0.94, 1.15; P-trend = 0.38), or major CVD (HR 0.92; 95% CI 0.83, 1.01; P-trend = 0.20). Similar results were observed in ONTARGET/TRANSCEND studies for composite outcome (HR 0.97; 95% CI 0.76, 1.25; P-trend = 0.09), total mortality (HR 0.88; 95% CI 0.62, 1.24; P-trend = 0.55), and major CVD (HR 0.97; 95% CI 0.73, 1.29; P-trend = 0.12).

CONCLUSIONS:

In 3 large international prospective studies including ∼177,000 individuals, 12,701 deaths, and 13,658 CVD events from 50 countries in 6 continents, we did not find significant associations between egg intake and blood lipids, mortality, or major CVD events. (AU)
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Brasil Contexto em Saúde: ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis Problema de saúde: Doença Cardiovascular Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Colesterol na Dieta / Doenças Cardiovasculares / Mortalidade Tipo de estudo: Ensaio clínico controlado / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Am. j. clin. nutr Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Aga Khan University/PK / Birzeit University/SA / Clinical Studies Latin America/AR / Dante Pazzanese Institute of Cardiology/BR / Dubai Medical University/AE / Eternal Heart Care Centre & Research Institute/IN / Fuwai Hospital/CN / Health Action by People/IN / Independent University Dhaka/IN / Isfahan University of Medical Sciences/IR

Texto completo: Disponível Coleções: Bases de dados nacionais / Brasil Contexto em Saúde: ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis Problema de saúde: Doença Cardiovascular Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Colesterol na Dieta / Doenças Cardiovasculares / Mortalidade Tipo de estudo: Ensaio clínico controlado / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Am. j. clin. nutr Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Aga Khan University/PK / Birzeit University/SA / Clinical Studies Latin America/AR / Dante Pazzanese Institute of Cardiology/BR / Dubai Medical University/AE / Eternal Heart Care Centre & Research Institute/IN / Fuwai Hospital/CN / Health Action by People/IN / Independent University Dhaka/IN / Isfahan University of Medical Sciences/IR
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