How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma
J. appl. oral sci
; 28: e20190198, 2020. tab, graf
Artigo
em Inglês
| LILACS, BBO - Odontologia
| ID: biblio-1056596
Biblioteca responsável:
BR28.1
ABSTRACT
Abstract Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. Objective:
The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC).Methodology:
In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005).Results:
Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS.Conclusion:
Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
BBO - Odontologia
/
LILACS
Assunto principal:
Neoplasias Bucais
/
Neoplasias da Língua
/
Carcinoma de Células Escamosas
/
Soalho Bucal
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. appl. oral sci
Assunto da revista:
Odontologia
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Canadá
Instituição/País de afiliação:
Instituto Nacional de Câncer/BR
/
Segal Cancer Centre/CA
/
Universidade Estadual do Rio de Janeiro/BR
/
Universidade Federal Fluminense/BR
/
Universidade Federal do Espírito Santo/BR