Your browser doesn't support javascript.
loading
Late Consequences of Acute Coronary Syndromes: Global Registry of Acute Coronary Events (GRACE)Follow-up
Alnasser, Sami M A; Goodman, Shaun G; Huang, Wei; Joel M. Gore; Steg, Gabriel; Eagle, Kim A; Anderson Jr, Frederick A; Fox, Keith A A; Gurfinkel, Enrique; Brieger, David; Klein, Werner; van de Werf, Frans; Avezum, Álvaro; Montalescot, Gilles; Gulba, Dietrich C; Budaj, Andrzej; Lopez Sendon, Jose; Granger, Christopher B; Kennelly, Brian M; Goldberg, Robert J; Fleming, Emily.
Afiliação
  • Alnasser, Sami M A; St. Michael’s Hospital. Ontario. CA
  • Goodman, Shaun G; St. Michael’s Hospital. Ontario. CA
  • Huang, Wei; University of Massachusetts MedicalSchool. Worcester. US
  • Joel M. Gore; University of Massachusetts MedicalSchool. Worcester. US
  • Steg, Gabriel; Université Paris 7, Centre Hospitalier Bichat-Claude Bernard. Paris. FR
  • Eagle, Kim A; University of Michigan Health System. Ann Arbor. US
  • Anderson Jr, Frederick A; University of Massachusetts Medical School. Worcester. US
  • Fox, Keith A A; University of Edinburgh. Edinburgh. GB
  • Gurfinkel, Enrique; ICYCC Favaloro Foundation. Buenos Aires. AR
  • Brieger, David; Concord Hospital and University of Sydney. Sydney. AU
  • Klein, Werner; Teaching Hospital of the Karl Franzens University Graz. Graz. AT
  • van de Werf, Frans; University Hospitals Leuven. Leuven. BE
  • Avezum, Álvaro; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Montalescot, Gilles; Centre Hospitalier Universitaire Pitié-Salpêtrière. Paris. FR
  • Gulba, Dietrich C; Department of Cardiology, KKO St Marien Hospital. Oberhausen. DE
  • Budaj, Andrzej; Postgraduate Medical School, Grochowski Hospital. Varsovia. PL
  • Lopez Sendon, Jose; Hospital Universitario La Paz. Madri. ES
  • Granger, Christopher B; Duke University Medical Center. Durham. US
  • Kennelly, Brian M; Hoag Memorial Hospital Presbyterian. Newport Beach. US
  • Goldberg, Robert J; University of Massachusetts Medical School. Worcester. US
  • Fleming, Emily; Canadian Heart Research Centre. Toronto. CA
Am. j. med ; 128(7): 766-775, 2015. ilus
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1059511
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT

PURPOSE:

Short-term outcomes have been well characterized in acute coronary syndromes; however,longer-term follow-up for the entire spectrum of these patients, including ST-segment-elevation myocardialinfarction, non-ST-segment-elevation myocardial infarction, and unstable angina, is more limited. Therefore,we describe the longer-term outcomes, procedures, and medication use in Global Registry of AcuteCoronary Events (GRACE) hospital survivors undergoing 6-month and 2-year follow-up, and the performanceof the discharge GRACE risk score in predicting 2-year mortality.

METHODS:

Between 1999 and 2007, 70,395 patients with a suspected acute coronary syndrome wereenrolled. In 2004, 2-year prospective follow-up was undertaken in those with a discharge acute coronarysyndrome diagnosis in 57 sites.

RESULTS:

From 2004 to 2007, 19,122 (87.2%) patients underwent follow-up; by 2 years postdischarge,14.3% underwent angiography, 8.7% percutaneous coronary intervention, 2.0% coronary bypass surgery,and 24.2% were re-hospitalized. In patients with 2-year follow-up, acetylsalicylic acid (88.7%), betablocker(80.4%), renin-angiotensin system inhibitor (69.8%), and statin (80.2%) therapy was used. Heartfailure occurred in 6.3%, (re)infarction in 4.4%, and death in 7.1%. Discharge-to-6-month GRACE riskscore was highly predictive of all-cause mortality at 2 years (c-statistic 0.80).

CONCLUSION:

In this large multinational cohort of acute coronary syndrome patients, there were importantlater adverse consequences, including frequent morbidity and mortality. These findings were seen in thecontext of additional coronary procedures and despite continued use of evidence-based therapies in a highproportion of patients. The discriminative accuracy of the GRACE risk score in hospital survivors forpredicting longer-term mortality was maintained.
Assuntos
Buscar no Google
Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Síndrome Coronariana Aguda / Infarto do Miocárdio / Revascularização Miocárdica Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Am. j. med Ano de publicação: 2015 Tipo de documento: Artigo Instituição/País de afiliação: Canadian Heart Research Centre/CA / Centre Hospitalier Universitaire Pitié-Salpêtrière/FR / Concord Hospital and University of Sydney/AU / Department of Cardiology, KKO St Marien Hospital/DE / Duke University Medical Center/US / Hoag Memorial Hospital Presbyterian/US / Hospital Universitario La Paz/ES / ICYCC Favaloro Foundation/AR / Instituto Dante Pazzanese de Cardiologia/BR / Postgraduate Medical School, Grochowski Hospital/PL
Buscar no Google
Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Síndrome Coronariana Aguda / Infarto do Miocárdio / Revascularização Miocárdica Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Am. j. med Ano de publicação: 2015 Tipo de documento: Artigo Instituição/País de afiliação: Canadian Heart Research Centre/CA / Centre Hospitalier Universitaire Pitié-Salpêtrière/FR / Concord Hospital and University of Sydney/AU / Department of Cardiology, KKO St Marien Hospital/DE / Duke University Medical Center/US / Hoag Memorial Hospital Presbyterian/US / Hospital Universitario La Paz/ES / ICYCC Favaloro Foundation/AR / Instituto Dante Pazzanese de Cardiologia/BR / Postgraduate Medical School, Grochowski Hospital/PL
...