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The dysfunction of ammonia in heart failure increases with an increase in the intensity of resistance exercise, even with the use of appropriate drug therapy
Medeiros, Wladimir M; Carvalho, Antonio C; Peres, Paulo; De Luca, Fabio A; Gun, Carlos.
Afiliação
  • Medeiros, Wladimir M; Universidade Federal de São Paulo (UNIFESP). Universidade de Santo Amaro (UNISA). São Paulo. BR
  • Carvalho, Antonio C; Universidade Federal de São Paulo (UNIFESP). São Paulo. BR
  • Peres, Paulo; Universidade Federal de São Paulo (UNIFESP). São Paulo. BR
  • De Luca, Fabio A; Universidade de Santo Amaro (UNISA). São Paulo. BR
  • Gun, Carlos; Instituto dante Pazzanese de Cardiologia. Universidade de Santo Amaro (UNISA). São Paulo. BR
Eur J Prev Cardiol ; 21(1): 135-144, 2014.
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1062627
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT

Background:

Hyperammonemia during rest periods is a dysfunction in heart failure (HF). The low formation of ammonia during exercise reflects an inefficiency of purine metabolism. Hyperkalemia in response to physical exercise is common in HF and may contribute to a contractile inefficiency in type II fibers, leading to early fatigue. We tested the hypothesis that during resistance exercise of high intensity and low volume, this disorder of ammonia metabolism would be more intense, due to the hyperkalemia present in HF.

Methods:

Alternating resistance exercise (RE) of low intensity and high volume, and high intensity and low volume, were applied to 18 patients with an interval of 7 days between them (functional class II-III New York Heart Association, FE = 33.5 ± 4%) and compared with 22 healthy controls matched for age and gender. Ammonia, potassium and lactate levels were assessed before and immediately after the RE.

Results:

Significant differences Deltas (control vs. HF) in 40% RE lactate (mg/dl) 26.3 ± 10 vs. 37.7 ± 7; p < 0,001, ammonia (ug/dl) 92.5 ± 18 vs. 48.9 ± 9; p < 0.001. Deltas (control vs. HF) in 80%RE lactate(mg/dl) 45.0 ± 12 vs. 54.1 ± 11; p < 0.05, ammonia(ug/dl) 133.5 ± 22 vs. 32.2 ± 7; p < 0.001, potassium (mEq/L) 1.6 ± 0.4 vs. 2.0 ± 0.8; p < 0.05. A negative correlation was found between the deltas of ammonia and potassium (r = −0.74, p < 0.001) in the HF group.

Conclusions:

We conclude that in HF, there is an inefficiency of purine metabolism that increases with increasing exercise intensity, but not with an increase of total volume. These findings suggest that hyperkalemia may play an important role in the disorders of purine metabolism.
Assuntos
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Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Ácido Láctico / Fadiga / Insuficiência Cardíaca / Contração Muscular Idioma: Inglês Revista: Eur J Prev Cardiol Ano de publicação: 2014 Tipo de documento: Artigo Instituição/País de afiliação: Instituto dante Pazzanese de Cardiologia/BR / Universidade Federal de São Paulo (UNIFESP)/BR / Universidade de Santo Amaro (UNISA)/BR
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Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Ácido Láctico / Fadiga / Insuficiência Cardíaca / Contração Muscular Idioma: Inglês Revista: Eur J Prev Cardiol Ano de publicação: 2014 Tipo de documento: Artigo Instituição/País de afiliação: Instituto dante Pazzanese de Cardiologia/BR / Universidade Federal de São Paulo (UNIFESP)/BR / Universidade de Santo Amaro (UNISA)/BR
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