Mast cell degranulation in periodontal disease from HIV-infected individuals
Braz. j. oral sci
; 18: e191445, jan.-dez. 2019. ilus
Artigo
em Inglês
| LILACS, BBO - Odontologia
| ID: biblio-1094900
Biblioteca responsável:
BR218.1
ABSTRACT
Aim:
The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART).Methods:
Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and tained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained.Results:
No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups.Conclusions:
There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
BBO - Odontologia
/
LILACS
Assunto principal:
Doenças Periodontais
/
HIV
/
Periodontite Crônica
/
Gengivite
/
Mastócitos
/
Mucosa Bucal
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. oral sci
Assunto da revista:
Odontologia
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
D'OR Institute for Research and Education/BR
/
Faculdade Arnaldo de Odontologia Belo Horizonte/BR
/
Pontifical Catholic University of Minas Gerais/BR
/
Universidade Federal de Minas Gerais/BR