Benznidazole as prophylaxis for Chagas Disease infection reactivation in heart transplant patients: a case series in Brazil
Trop. Med. Infect. Dis
; 5(3): 1-6, Aug., 2020. tab.
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1121993
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
ABSTRACT BackgroundPatients with Chagas cardiomyopathy (CC) have high mortality, and CC is a common indication for heart transplantation (HTx) in endemic countries. Chagas disease reactivation (CDR) is common after transplantation and is likely to cause adverse outcomes unless detected and treated appropriately. This study reviews our experiences with HTx among patients with CC, and the use of benznidazole (BZ) before transplantation. METHODSDuring the 18-year period from 1996 through 2014, 70 of 353 patients who underwent HTx (19.8%) had CC, and 53 patients met the inclusion criteria. The e_ectiveness of prophylactic treatment with BZ (dose of 5 mg/kg/day, two times per day, for at least four weeks and for a maximum of eight weeks) was determined based on the observed reduction in the incidence of CDR during the post-HTx period. RESULTSProphylactic therapy was administered to 18/53 patients (34.0%). During the follow-up period, the incidence rate of CDR in our study was 34.0% (18/53). Based on logistic regression analysis, only prophylaxis (OR = 0.12; CI 0.020.76; p = 0.025) was considered to protect against CDR. CONCLUSIONOur study suggests that the use of BZ may reduce the incidence of CDR in patients undergoing HTx and warrants further investigation in a prospective, randomized trial.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Doença de Chagas
/
Doenças Negligenciadas
/
Doença de Chagas
/
Doença Cardiovascular
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Cardiomiopatia Chagásica
/
Transplante de Coração
/
Doença de Chagas
Tipo de estudo:
Ensaio clínico controlado
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Trop. Med. Infect. Dis
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Dante Pazzanese de Cardiologia/BR