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Continuous positive airway pressure treatment, glycemia, and diabetes risk in obstructive sleep apnea and comorbid cardiovascular disease
Loffler, Kelly A; Heeley, Emma; Freed, Ruth; Meng, Rosie; Bittencourt, Lia R; Carvalho, Carolina C Gonzaga; Chen, Rui; Hlavac, Michael; Liu, Zhihong; Lorenzi-Filho, Geraldo; Luo, Yuanming; McArdle, Nigel; Mukherjee, Sutapa; Yap, Hooi Shan; Zhang, Xilong; Palmer, Lyle J; Anderson, Craig S; McEvoy, R Doug; Drager, Luciano F.
Afiliação
  • Loffler, Kelly A; Flinders University. Adelaide. AU
  • Heeley, Emma; Flinders University. University of New South Wales. Adelaide. AU
  • Freed, Ruth; University of New South Wales. Sydney. AU
  • Meng, Rosie; Flinders University. Adelaide. AU
  • Bittencourt, Lia R; Associação Fundo de Incentivo a Pesquisa. Instituto do Sono. São Paulo. BR
  • Carvalho, Carolina C Gonzaga; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Chen, Rui; The Second Affiliated Hospital of Soochow University. Sucheu. CN
  • Hlavac, Michael; Christchurch Hospital. Christchurch. NZ
  • Liu, Zhihong; Fuwai Hospital. Beijing. CN
  • Lorenzi-Filho, Geraldo; University of São Paulo. Instituto do Coração. São Paulo. BR
  • Luo, Yuanming; State Key Laboratory of Respiratory Disease. Hospital of Guangzhou Medical University. Guangdong. CN
  • McArdle, Nigel; Sir Charles Gairdner Hospital. Nedlands. AU
  • Mukherjee, Sutapa; Flinders University. Sir Charles Gairdner Hospital. Nedlands. AU
  • Yap, Hooi Shan; Southern Adelaide Local Health Network. Adelaide. AU
  • Zhang, Xilong; Hospital of Nanjing Medical University. Jiangsu. CN
  • Palmer, Lyle J; University of Adelaide. Adelaide. AU
  • Anderson, Craig S; University of New South Wales. University Health Science Center. Beijing. CN
  • McEvoy, R Doug; Flinders University. Southern Adelaide Local Health Network. Adelaide. AU
  • Drager, Luciano F; University Health Science Center. Beijing. CN
Diabetes care ; 43(8): 1859-1867, Aug., 2020.
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1128179
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT

OBJECTIVE:

Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve metabolic parameters. We sought to determine effects of long-term continuous positive airway pressure (CPAP) treatment on glycemic control and diabetes risk in patients with cardiovascular disease (CVD) and OSA. RESEARCH DESIGN AND

METHODS:

Blood, medical history, and personal data were collected in a substudy of 888 participants in the Sleep Apnea cardioVascular Endpoints (SAVE) trial in which patients with OSA and stable CVD were randomized to receive CPAP plus usual care, or usual care alone. Serum glucose and glycated hemoglobin A1c (HbA1c) were measured at baseline, 6 months, and 2 and 4 years and incident diabetes diagnoses recorded.

RESULTS:

Median follow-up was 4.3 years. In those with preexisting diabetes (n = 274), there was no significant difference between the CPAP and usual care groups in serum glucose, HbA1c, or antidiabetic medications during follow-up. There were also no significant between-group differences in participants with prediabetes (n = 452) or new diagnoses of diabetes. Interaction testing suggested that women with diabetes did poorly in the usual care group, while their counterparts on CPAP therapy remained stable.

CONCLUSIONS:

Among patients with established CVD and OSA, we found no evidence that CPAP therapy over several years affects glycemic control in those with diabetes or prediabetes or diabetes risk over standard-of-care treatment. The potential differential effect according to sex deserves further investigation.
Assuntos
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Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Glicemia / Pressão Positiva Contínua nas Vias Aéreas Tipo de estudo: Ensaio clínico controlado / Estudo diagnóstico / Estudo de etiologia / Fatores de risco Idioma: Inglês Revista: Diabetes care Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Associação Fundo de Incentivo a Pesquisa/BR / Christchurch Hospital/NZ / Flinders University/AU / Fuwai Hospital/CN / Hospital of Nanjing Medical University/CN / Instituto Dante Pazzanese de Cardiologia/BR / Sir Charles Gairdner Hospital/AU / Southern Adelaide Local Health Network/AU / State Key Laboratory of Respiratory Disease/CN / The Second Affiliated Hospital of Soochow University/CN
Buscar no Google
Coleções: Bases de dados nacionais / Brasil Base de dados: Sec. Est. Saúde SP / SESSP-IDPCPROD Assunto principal: Glicemia / Pressão Positiva Contínua nas Vias Aéreas Tipo de estudo: Ensaio clínico controlado / Estudo diagnóstico / Estudo de etiologia / Fatores de risco Idioma: Inglês Revista: Diabetes care Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Associação Fundo de Incentivo a Pesquisa/BR / Christchurch Hospital/NZ / Flinders University/AU / Fuwai Hospital/CN / Hospital of Nanjing Medical University/CN / Instituto Dante Pazzanese de Cardiologia/BR / Sir Charles Gairdner Hospital/AU / Southern Adelaide Local Health Network/AU / State Key Laboratory of Respiratory Disease/CN / The Second Affiliated Hospital of Soochow University/CN
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