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Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study
Nery, Fabiano G.; Wilson, Anna R.; Schneider, Marguerite R.; Strawn, Jeffrey R.; Patino, Luis R.; McNamara, Robert K.; Adler, Caleb M.; Strakowski, Stephen M.; DelBello, Melissa P..
Afiliação
  • Nery, Fabiano G.; University of Cincinnati College of Medicine. Department of Psychiatry and Behavioral Neuroscience. Cincinnati. US
  • Wilson, Anna R.; University of Cincinnati College of Medicine. Department of Psychiatry and Behavioral Neuroscience. Cincinnati. US
  • Schneider, Marguerite R.; Harvard Longwood Psychiatry Residency Training Program. Boston. US
  • Strawn, Jeffrey R.; University of Cincinnati College of Medicine. Department of Psychiatry and Behavioral Neuroscience. Cincinnati. US
  • Patino, Luis R.; University of Cincinnati College of Medicine. Department of Psychiatry and Behavioral Neuroscience. Cincinnati. US
  • McNamara, Robert K.; University of Cincinnati College of Medicine. Department of Psychiatry and Behavioral Neuroscience. Cincinnati. US
  • Adler, Caleb M.; University of Cincinnati College of Medicine. Department of Psychiatry and Behavioral Neuroscience. Cincinnati. US
  • Strakowski, Stephen M.; University of Texas at Austin. Dell Medical School. Department of Psychiatry. Austin. US
  • DelBello, Melissa P.; University of Cincinnati College of Medicine. Department of Psychiatry and Behavioral Neuroscience. Cincinnati. US
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 42(5): 481-488, Sept.-Oct. 2020. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1132115
Biblioteca responsável: BR1.1
ABSTRACT

Objectives:

To prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder.

Methods:

Youth aged 9-20 years with at least one biological parent with bipolar disorder and no prior history of mood or psychotic episodes (n=93) were prospectively evaluated and treated naturalistically during the study. Participants were divided into two groups converters, defined as those who met DSM-IV criteria for a mood episode during follow-up (n=19); or non-converters (n=74). Logistic regression models were used to investigate associations between baseline clinical variables and medication exposure during follow-up and risk of developing a first mood episode (conversion).

Results:

Multivariate regression analyses showed that baseline anxiety disorders and subsyndromal mood disorders were associated with increased risk of conversion during follow-up. Adding medication exposure to the multivariate model showed that exposure to antidepressants during follow-up was associated with increased risk of conversion.

Conclusions:

Caution should be used when treating bipolar offspring with anxiety and/or emerging depressive symptoms using antidepressant agents, given the increased risk of developing a major mood disorder.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Assunto da revista: Psiquiatria Ano de publicação: 2020 Tipo de documento: Artigo / Documento de projeto Instituição/País de afiliação: Harvard Longwood Psychiatry Residency Training Program/US / University of Cincinnati College of Medicine/US / University of Texas at Austin/US

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Assunto da revista: Psiquiatria Ano de publicação: 2020 Tipo de documento: Artigo / Documento de projeto Instituição/País de afiliação: Harvard Longwood Psychiatry Residency Training Program/US / University of Cincinnati College of Medicine/US / University of Texas at Austin/US