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Correlating cognition and cortical excitability with pain in fibromyalgia: a case control study
Tiwari, Vikas Kumar; Nanda, Srishti; Arya, Suvercha; Kumar, Uma; Sharma, Ratna; Kumaran, Senthil S; Bhatia, Renu.
Afiliação
  • Tiwari, Vikas Kumar; All India Institute of Medical Sciences. Department of Physiology. Pain Research and TMS Laboratory. New Delhi. IN
  • Nanda, Srishti; All India Institute of Medical Sciences. Department of Physiology. Pain Research and TMS Laboratory. New Delhi. IN
  • Arya, Suvercha; All India Institute of Medical Sciences. Department of Physiology. Pain Research and TMS Laboratory. New Delhi. IN
  • Kumar, Uma; All India Institute of Medical Sciences. Department of Rheumatology. New Delhi. IN
  • Sharma, Ratna; All India Institute of Medical Sciences. Department of Physiology. Stress and Cognition Electroimaging Laboratory. New Delhi. IN
  • Kumaran, Senthil S; All India Institute of Medical Sciences. Department of Nuclear Magnetic Resonance and MRI Facility. New Delhi. IN
  • Bhatia, Renu; All India Institute of Medical Sciences. Department of Physiology. Pain Research and TMS Laboratory. New Delhi. IN
Adv Rheumatol ; 61: 10, 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1152740
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Background:

Fibromyalgia is a chronic pain disorder characterized by widespread musculoskeletal symptoms, primarily attributed to sensitization of somatosensory system carrying pain. Few reports have investigated the impact of fibromyalgia symptoms on cognition, corticomotor excitability, sleepiness, and the sleep quality — all of which can deteriorate the quality of life in fibromyalgia. However, the existing reports are underpowered and have conflicting directions of findings, limiting their generalizability. Therefore, the present study was designed to compare measures of cognition, corticomotor excitability, sleepiness, and sleep quality using standardized instruments in the recruited patients of fibromyalgia with pain-free controls.

Methods:

Diagnosed cases of fibromyalgia were recruited from the Rheumatology department for the cross-sectional, case-control study. Cognition (Mini-Mental State Examination, Stroop color-word task), corticomotor excitability (Resting motor threshold, Motor evoked potential amplitude), daytime sleepiness (Epworth sleepiness scale), and sleep quality (Pittsburgh sleep quality index) were studied according to the standard procedure.

Results:

Thirty-four patients of fibromyalgia and 30 pain-free controls were recruited for the study. Patients of fibromyalgia showed decreased cognitive scores (p = 0.05), lowered accuracy in Stroop color-word task (for color 0.02, for word 0.01), and prolonged reaction time (< 0.01, < 0.01). Excessive daytime sleepiness in patients were found (< 0.01) and worsened sleep quality (< 0.01) were found. Parameters of corticomotor excitability were comparable between patients of fibromyalgia and pain-free controls.

Conclusions:

Patients of fibromyalgia made more errors, had significantly increased reaction time for cognitive tasks, marked daytime sleepiness, and impaired quality of sleep. Future treatment strategies may include cognitive deficits and sleep disturbances as an integral part of fibromyalgia management.(AU)
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas Problema de saúde: Objetivo 9: Redução de doenças não transmissíveis Base de dados: LILACS Assunto principal: Fibromialgia / Cognição / Dor Crônica / Higiene do Sono / Excitabilidade Cortical Tipo de estudo: Estudo observacional / Estudo de prevalência / Fatores de risco Aspecto: Preferência do paciente Limite: Humanos Idioma: Inglês Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: All India Institute of Medical Sciences/IN

Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas Problema de saúde: Objetivo 9: Redução de doenças não transmissíveis Base de dados: LILACS Assunto principal: Fibromialgia / Cognição / Dor Crônica / Higiene do Sono / Excitabilidade Cortical Tipo de estudo: Estudo observacional / Estudo de prevalência / Fatores de risco Aspecto: Preferência do paciente Limite: Humanos Idioma: Inglês Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: All India Institute of Medical Sciences/IN
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