Efficacy and safety of Morinda officinalis oligosaccharide capsules for depressive disorder: a systematic review and meta-analysis
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 43(3): 306-313, May-June 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1249200
Biblioteca responsável:
BR1.1
ABSTRACT
Objective:
To evaluate the efficacy and safety of Morinda officinalis oligosaccharide (MOO) capsules for depressive disorder.Methods:
Eight electronic databases were searched for relevant studies from inception to April 19, 2020. Randomized controlled trials comparing MOO capsules with antidepressants were included. Data analysis was conducted using Review Manager 5.3 software. The risk of bias was assessed using the Cochrane Risk of Bias Tool, and the quality of the studies was evaluated by two researchers using the Grading of Recommendation, Assessment, Development and Evaluations (GRADE) software.Results:
Seven studies involving 1,384 participants were included in this study. The effect of MOO capsules for moderate depressive disorder was not different from that of antidepressants (risk ratio [RR] = 0.99, 95%CI 0.92-1.06). Regarding adverse events, no significant difference was found between MOO capsules and antidepressants (RR = 0.84, 95%CI 0.65-1.07). In addition, the quality of evidence related to these adverse events was rated as low.Conclusion:
This systematic review suggests that the efficacy of MOO capsules in the treatment of mild to moderate depression is not inferior to that of conventional antidepressants, which may provide a new direction for clinical alternative selection of antidepressants. However, more high-quality research and detailed assessments are needed.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Morinda
/
Transtorno Depressivo
Tipo de estudo:
Ensaio clínico controlado
/
Guia de prática clínica
/
Revisão sistemática
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Beijing University of Chinese Medicine/CN
/
Capital Medical University/CN
/
Shanghai Jiao Tong University School of Medicine/CN