Your browser doesn't support javascript.
loading
Immunohistochemistry analysis of checkpoint kinase 2 in oral squamous cell carcinoma
Cardoso, Suziene Caroline Silva; Duarte, Andressa; Almeida, Luciana Yamamoto de; León, Jorge Esquiche; Ribeiro-Silva, Alfredo.
Afiliação
  • Cardoso, Suziene Caroline Silva; Department of Pathology and Forensic Medicine. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto. BR
  • Duarte, Andressa; Department of Pathology and Forensic Medicine. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto. BR
  • Almeida, Luciana Yamamoto de; Hematology Division, Department of Clinical Medicine. Ribeirão Preto Medical School (FMRP/USP). University of São Paulo. Ribeirão Preto. BR
  • León, Jorge Esquiche; Department of Stomatology, Collective Health and Legal Dentistry. Ribeirão Preto School of Medicine. University of São Paulo. Ribeirão Preto. BR
  • Ribeiro-Silva, Alfredo; Department of Pathology and Forensic Medicine. Ribeirão Preto Medical School. University of São Paulo. São Paulo. BR
Appl. cancer res ; 40: 1-6, Oct. 19, 2020. ilus, tab
Artigo em Inglês | LILACS, Inca | ID: biblio-1282611
Biblioteca responsável: BR30.1
Localização: BR30.1
ABSTRACT

Background:

Oral squamous cell carcinoma (OSCC) is the most frequently occurring malignant tumor of the head and neck region. Chk2 (Checkpoint kinase 2) is considered a tumor suppressor gene that acts on the cellular response to DNA damage. However, the role of Chk2 in OSCC prognosis is not yet fully understood. The objective of this study was to evaluate Chk2 immunoexpression in OSCC and to elucidate the association between its expression and clinicopathological parameters of prognostic importance, including overall survival, disease-free survival, and metastasis-free survival.

Methods:

Chk2 expression was analyzed in 101 samples from patients with OSCC using immunohistochemistry. We stratified the patients into high expression (> 66% of cells positive for Chk2) and low expression (< 66%) groups.

Results:

Chk2 showed high expression in 57.43% of OSCC. In our study, the expression of Chk2 did not correlate with any of the prognostic parameters evaluated. There was no difference between overall survival, metastasis-free survival, and disease-free survival according to Chk2 expression.

Conclusion:

Despite the great importance of Chk2 in the development of different types of cancer, our findings do not favor Chk2 as a prognostic marker in oral squamous cell carcinoma.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS / Inca Assunto principal: Neoplasias Bucais / Imuno-Histoquímica / Carcinoma de Células Escamosas / Quinase do Ponto de Checagem 2 Tipo de estudo: Estudo prognóstico Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Appl. cancer res Assunto da revista: Neoplasias Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Department of Pathology and Forensic Medicine/BR / Department of Stomatology, Collective Health and Legal Dentistry/BR / Hematology Division, Department of Clinical Medicine/BR

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS / Inca Assunto principal: Neoplasias Bucais / Imuno-Histoquímica / Carcinoma de Células Escamosas / Quinase do Ponto de Checagem 2 Tipo de estudo: Estudo prognóstico Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Appl. cancer res Assunto da revista: Neoplasias Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Department of Pathology and Forensic Medicine/BR / Department of Stomatology, Collective Health and Legal Dentistry/BR / Hematology Division, Department of Clinical Medicine/BR
...