Transfusion practices in cirrhotic patients at a tertiary liver care center from Northern India
Hematol., Transfus. Cell Ther. (Impr.)
; 43(3): 280-286, July-Sept. 2021. tab, ilus
Artigo
em Inglês
| LILACS
| ID: biblio-1346270
Biblioteca responsável:
BR408.1
Localização: BR408.1
ABSTRACT
Abstract Introduction:
Transfusion in cirrhotic patients remains a challenge due to the absence of evidence-based guidelines. Our study aimed to determine the indication of transfusion and the associated transfusion thresholds in cirrhotic patients.Methods:
This retrospective observational study was conducted in the Department of Transfusion Medicine at a tertiary care liver center from October 2018 to March 2019. The blood bank and patient records of cirrhotic patients admitted during the study period were retrieved and analyzed to determine the current transfusion practice.Results:
A total of 992 cirrhotic patients were included in the study. Blood components were transfused to 402 (40.5%) patients. Sixty-nine (17.2%) patients were transfused to control/treat active bleeding, while 333 (82.8%) were transfused prophylactically. Packed red blood cells (65.4%) was the most commonly transfused blood component, followed by fresh frozen plasma (35.6%), among patients receiving transfusions (therapeutic & prophylactic). The mean pre-transfusion thresholds for (i) packed red blood cell transfusion hemoglobin less than 7 g/dL; (ii) fresh frozen plasma transfusion international normalized ratio over 2.6; (iii) platelet concentrate transfusion platelet count less than 40,700/µL, and; (iv) cryoprecipitate transfusion fibrinogen less than 110 mg/dL. The average length of stay of the study population was 5 days (3-9.Conclusion:
To conclude, 40.5% of our hospitalized cirrhotic patients were transfused, with the majority of the transfusions being prophylactic (82.8%). Separate guidelines are required for this patient population, as these patients have an altered hemostasis which responds differently to the transfusion of blood components.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Transtornos da Coagulação Sanguínea
/
Transfusão de Sangue
/
Cirrose Hepática
Tipo de estudo:
Guia de prática clínica
/
Estudo observacional
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Hematol., Transfus. Cell Ther. (Impr.)
Assunto da revista:
Hematologia
/
TransfusÆo de Sangue
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Índia
Instituição/País de afiliação:
Institute of Liver and Biliary Sciences/IN