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Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline
Møller, Morten; Alhazzani, Walled; Lewis, Kimberley; Belley-Cote, Emilie; Granholm, Anders; Centofanti, John; Mclntyre, William; Spence, Jessica.
Afiliação
  • Møller, Morten; Copenhagen University. Hospital Rigshospitalet. Department of Intensive Care,. Copenhagen. DK
  • Alhazzani, Walled; McMaster University. Department of Medicine. Division of Critical Care. Hamilton. CA
  • Lewis, Kimberley; McMaster University. Department of Medicin. Division of Critical Care. Hamilton. CA
  • Belley-Cote, Emilie; McMaster University. Divisions of Cardiology and Critical Care. Hamilton. CA
  • Granholm, Anders; Copenhagen University. Hospital Rigshospitalet,. Department of Intensive Care,. Copenhagen. DK
  • Centofanti, John; McMaster University. Department of Anesthesia. Hamilton. CA
  • Mclntyre, William; Population Health Research Institute. Hamilton. CA
  • Spence, Jessica; McMaster University. Department of Medicine. Hamilton. CA
Artigo em Inglês | BIGG - guias GRADE | ID: biblio-1372808
Biblioteca responsável: BR1.1
ABSTRACT
The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM­RPG) was to formulate evidence­based guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the intensive care unit (ICU). We adhered to the methodology for trustworthy clinical practice guidelines, including use of the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the certainty of evidence, and the Evidence-to-Decision framework to generate recommendations. The guideline panel comprised 28 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. Through teleconferences and web­based discussions, the panel provided input on the balance and magnitude of the desirable and undesirable effects, the certainty of evidence, patients' values and preferences, costs and resources, feasibility, acceptability, and research priorities. The ICM­RPG panel issued one weak recommendation (suggestion) based on overall moderate certainty of evidence "In invasively mechanically ventilated adult ICU patients, we suggest using dexmedetomidine over other sedative agents, if the desirable effects including a reduction in delirium are valued over the undesirable effects including an increase in hypotension and bradycardia". This ICM-RPG provides updated evidence-based guidance on the use of dexmedetomidine for sedation in mechanically ventilated adults, and outlines uncertainties and research priorities.
Licença
C - All Rights Reserved
Assuntos


Texto completo: Disponível Coleções: Bases de dados temática Base de dados: BIGG - guias GRADE Assunto principal: Respiração Artificial / Dexmedetomidina / Sedação Profunda / Unidades de Terapia Intensiva Tipo de estudo: Guia de prática clínica / Estudo prognóstico / Pesquisa qualitativa Idioma: Inglês Revista: Intensive care med Ano de publicação: 2022 Tipo de documento: Artigo Instituição/País de afiliação: Copenhagen University/DK / McMaster University/CA / Population Health Research Institute/CA

Texto completo: Disponível Coleções: Bases de dados temática Base de dados: BIGG - guias GRADE Assunto principal: Respiração Artificial / Dexmedetomidina / Sedação Profunda / Unidades de Terapia Intensiva Tipo de estudo: Guia de prática clínica / Estudo prognóstico / Pesquisa qualitativa Idioma: Inglês Revista: Intensive care med Ano de publicação: 2022 Tipo de documento: Artigo Instituição/País de afiliação: Copenhagen University/DK / McMaster University/CA / Population Health Research Institute/CA
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