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Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies
Soma, Deepthi; Attari, Zenab; Reddy, Meka Sreenivasa; Damodaram, Atmakuri; Koteshwara, Kunnatur Balasundara Gupta.
Afiliação
  • Soma, Deepthi; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmaceutics. Manipal. IN
  • Attari, Zenab; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmaceutics. Manipal. IN
  • Reddy, Meka Sreenivasa; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmaceutics. Manipal. IN
  • Damodaram, Atmakuri; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmaceutics. Manipal. IN
  • Koteshwara, Kunnatur Balasundara Gupta; Manipal University. Manipal College of Pharmaceutical Sciences. Department of Pharmaceutics. Manipal. IN
Braz. J. Pharm. Sci. (Online) ; 53(1): e15012, 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-839440
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT Irbesartan is an antihypertensive with limited bioavailability and solid lipid nanoparticles (SLN) is one of the approaches to improve bioavailability. Solid lipid nanoparticles were prepared using glyceryl monostearate by solvent emulsification method followed by probe sonication. Irbesartan loaded SLNs were characterized and optimized by parameters like particle size, zeta potential, surface morphology entrapment efficiency and in vitro release. The optimized formulation was then further evaluated for the pharmacokinetic studies in Wistar rats. Irbesartan-loaded SLN of particle size 523.7 nm and 73.8% entrapment efficiency showed good bioavailability in Wistar rats and also showed optimum stability in the studies. The SLN prepared using glyceryl monostearate by solvent emulsification method leads to improve bioavailability of the drug.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Angiotensinas / Nanopartículas / Anti-Hipertensivos Limite: Animais Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Manipal University/IN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Angiotensinas / Nanopartículas / Anti-Hipertensivos Limite: Animais Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Manipal University/IN
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