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1, 3, 4-Thiadiazole and 1, 2, 4-triazole-3(4 H )-thione bearing salicylate moiety: synthesis and evaluation as anti- Candida albicans
Radwan, Awwad Abdoh; Alanazi, Fares Kaed; Al-Agamy, Mohammed Hamed.
Afiliação
  • Radwan, Awwad Abdoh; King Saud University. College of Pharmacy. Kayyali Chai. Riyadh. SA
  • Alanazi, Fares Kaed; King Saud University. College of Pharmacy. Kayyali Chai. Riyadh. SA
  • Al-Agamy, Mohammed Hamed; King Saud University. College of Pharmacy. Department of Pharmaceutics. Riyadh. SA
Braz. J. Pharm. Sci. (Online) ; 53(1): e15239, 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-839464
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Dramatically increased occurrence of both superficial and invasive fungal infections has been observed. Candida albicans appear to be the main etiological agent of invasive fungal infections. The anti-C. albicans activity of thiosemicarbazide, 1,3,4-Thiadiazole, and 1,2,4-triazole-3(4H)-thione compounds (compounds 3-23) were investigated. The MIC values of thiadiazole and triazole derivatives 10-23 were in the range of 0.08-0.17 µmol mL-1, while that of fluconazole was 0.052 µmol mL-1. Compound 11 (5-(2-(4-chlorobenzyloxy)phenyl)-N-allyl-1,3,4-thiadiazol-2-amine) and compound 18 (5-(2-(4-chlorobenzyloxy)phenyl)-4-allyl-2H-1,2,4-triazole-3(4H)-thione) were found to be the most active compounds, with MIC values of 0.08 µmol mL-1. The newly synthesized thiadiazole and triazole compounds (compounds 10-23) showed promising anti-Candida activity. The allyl substituent-bearing compounds 11 and 18 exhibited significant anti-Candida albicans activity and showed a binding mode as well as the fluconazole x-ray structure.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Tiadiazóis / Triazóis / Candida albicans / Salicilatos Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2017 Tipo de documento: Artigo / Documento de projeto País de afiliação: Arábia Saudita Instituição/País de afiliação: King Saud University/SA

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Tiadiazóis / Triazóis / Candida albicans / Salicilatos Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2017 Tipo de documento: Artigo / Documento de projeto País de afiliação: Arábia Saudita Instituição/País de afiliação: King Saud University/SA
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