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Study of the protective effect of dexamethasone on cisplatin-induced ototoxicity in rats
Capelo, Isabelle Oliveira Jatai; Batista, Avner Marcos Alves; Brito, Yuri Neyson Ferreira; Diniz, Krissia Braga; Brito, Gerly Anne de Castro; Freitas, Marcos Rabelo de.
Afiliação
  • Capelo, Isabelle Oliveira Jatai; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Batista, Avner Marcos Alves; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Brito, Yuri Neyson Ferreira; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Diniz, Krissia Braga; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Brito, Gerly Anne de Castro; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Freitas, Marcos Rabelo de; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
Acta cir. bras ; 32(10): 873-880, Oct. 2017. graf
Artigo em Inglês | LILACS | ID: biblio-886168
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Purpose:

To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity.

Methods:

Male Wistar rats were divided into the following three groups 1) Control (C) 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP 11 animals received 8 ml/kg/day of IP saline and, 90 min after saline administration, 8 mg/kg/day of IP CDDP for four days; and 3) DEXA15 + CDDP 11 animals received IP dexamethasone 15 mg/kg/day and, 90 min after dexamethasone administration, received 8 mg/kg/day of IP CDDP for four days.

Results:

It was found that dexamethasone did not protect against weight loss in CDDP-exposed animals. The mortality rate was comparable with that previously reported in the literature. The auditory threshold of animals in the DEXA15 + CDDP group was not significantly altered after exposure to CDDP. The stria vascularis of animals in the DEXA15 + CDDP group was partially preserved after CDDP exposure.

Conclusions:

Dexamethasone at the dose of 15 mg/kg/day partially protected against CDDP-induced ototoxicity, based on functional evaluation by brainstem evoked response audiontry (BERA) and morphological evaluation by optical microscopy. However, dexamethasone did not protect against systemic toxicity.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Limiar Auditivo / Dexametasona / Cisplatino / Cóclea / Substâncias Protetoras / Antineoplásicos Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal do Ceará/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Limiar Auditivo / Dexametasona / Cisplatino / Cóclea / Substâncias Protetoras / Antineoplásicos Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal do Ceará/BR
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