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Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo
Ramos, Mariana Gontijo; Ramos, Daniel Gontijo; Ramos, Camila Gontijo.
Afiliação
  • Ramos, Mariana Gontijo; Universidade Fumec. College of Human, Social, and Health Sciences. Belo Horizonte. BR
  • Ramos, Daniel Gontijo; Universidade Fumec. College of Human, Social, and Health Sciences. Belo Horizonte. BR
  • Ramos, Camila Gontijo; Universidade Fumec. College of Human, Social, and Health Sciences. Belo Horizonte. BR
An. bras. dermatol ; 92(3): 312-318, May-June 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-886974
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Background:

Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases.

Objectives:

To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo.

Methods:

Case series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects. The maximum follow-up period for some patients was 24 months.

Results:

Of the 20 patients who underwent 24 procedures, 25% showed an excellent rate of repigmentation, 50% good repigmentation, 15% regular, and 10% poor response. The best results were observed in face and neck lesions, while the worst in extremity lesions (88% and 33% of satisfactory responses, respectively). Patients with segmental vitiligo had a better response (84%) compared to non-segmental ones (63%). As side effects were observed hyperpigmentation of the treated area and the appearance of Koebner phenomenon in the donor area. Study

limitations:

Some limitations of the study included the small number of patients, a subjective evaluation, and the lack of long-term follow-up on the results.

CONCLUSION:

Noncultured epidermal cell suspension transplantation is efficient and well tolerated for stable vitiligo treatment, especially for segmental vitiligo on the face and neck.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Vitiligo / Queratinócitos / Melanócitos Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: An. bras. dermatol Assunto da revista: Dermatologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Fumec/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Vitiligo / Queratinócitos / Melanócitos Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: An. bras. dermatol Assunto da revista: Dermatologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Fumec/BR
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