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Episodic angioedema associated with eosinophilia
Liu, Fang; Hu, Wenxing; Liu, Haibo; Zhang, Min; Sang, Hong.
Afiliação
  • Liu, Fang; Nanjing University School of Medicine. Jinling Hospital. Department of Dermatology. Jiangsu. CN
  • Hu, Wenxing; Nanjing University School of Medicine. Jinling Hospital. Department of Dermatology. Jiangsu. CN
  • Liu, Haibo; Nanjing University School of Medicine. Jinling Hospital. Department of Dermatology. Jiangsu. CN
  • Zhang, Min; Nanjing University School of Medicine. Jinling Hospital. Department of Dermatology. Jiangsu. CN
  • Sang, Hong; Nanjing University School of Medicine. Jinling Hospital. Department of Dermatology. Jiangsu. CN
An. bras. dermatol ; 92(4): 534-536, July-Aug. 2017. graf
Artigo em Inglês | LILACS | ID: biblio-887014
Biblioteca responsável: BR1.1
ABSTRACT
Abstract We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89.9% eosinophils, followed by elevated serum level of IL-5, IgE, IgM, and LDH. Histopathology showed perivascular eosinophilic infiltration and diffuse eosinophilic infiltration throughout the dermis. Possible causes of hypereosinophilia and eosinophilic infiltration of vital organs were ruled out. We also tested the FIP1L1/PDGFRa and ETV6/PDGFRb fusion gene to exclude the possibility of myeloid and lymphatic vessel neoplasms. The patient was treated with methylprednisolone and discharged with an oral prednisolone taper, which resulted in complete remission of the edema and normalization of peripheral blood eosinophil count, serum IL-5 level, IgE, IgM, and LDH.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Eosinofilia / Angioedema Tipo de estudo: Fatores de risco Limite: Criança / Feminino / Humanos Idioma: Inglês Revista: An. bras. dermatol Assunto da revista: Dermatologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Nanjing University School of Medicine/CN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Eosinofilia / Angioedema Tipo de estudo: Fatores de risco Limite: Criança / Feminino / Humanos Idioma: Inglês Revista: An. bras. dermatol Assunto da revista: Dermatologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Nanjing University School of Medicine/CN
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