Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients
An. bras. dermatol
; 92(6): 811-815, Nov.-Dec. 2017. tab
Artigo
em Inglês
| LILACS
| ID: biblio-887118
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Background:
The onset of vitiligo during childhood is common. Limited data exist that compare the clinical associations of prepubertal and postpubertal vitiligo in Arabs.Objective:
To compare the clinical profile of pre and postpubertal onset vitiligo.Methods:
A cross-sectional observational study was conducted. The Vitiligo European Task Force questionnaire was completed for each patient.Results:
A total of 375 patients were included; 199 had postpubertal vitiligo (>12 years), and 176 had prepubertal onset vitiligo (<12years). There were more females in the prepubertal group (49%) than in the postpubertal group (29%), p-value <0.001. The prepubertal group has had more involvement than the postpubertal group (45% vs 30%, p=0.004). Only 8 cases of segmental vitiligo were observed; five were observed in the prepubertal group of patients. Female gender (OR=2.3; 95% CI1.5, 3.5), presence of halo nevus (OR=2.2; 95% CI1.1, 4.4) and face involvement (OR=1.9; 95% CI1.2, 2.9) were positively associated with prepubertal vitiligo. Stress, as an onset factor, was positively associated (OR=0.51; 95% CI0.3, 0.8) with postpubertal onset vitiligo. Studylimitations:
A possible selection bias toward more severe vitiligo cases can be a limitation, because the study was conducted in a clinic specialized in vitiligo. Moreover, a likelihood of false recall bias cannot be excluded.Conclusions:
Our data present clinical evidence that vitiligo behaves mostly the same way in the prepubertal group as in the postpubertal group. However, female over-representation, more face involvement and more halo nevi were observed in prepubertal vitiligo, while stress was more prevalent as an aggravating factor in postpubertal vitiligo patients.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Vitiligo
/
Puberdade
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Arábia Saudita
Instituição/País de afiliação:
King Saud University/SA