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Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients
Khurrum, Huma; AlGhamdi, Khalid M.
Afiliação
  • Khurrum, Huma; King Saud University. College of Medicine. Vitiligo Research Chair. Riyadh. SA
  • AlGhamdi, Khalid M; King Saud University. College of Medicine. Vitiligo Research Chair. Riyadh. SA
An. bras. dermatol ; 92(6): 811-815, Nov.-Dec. 2017. tab
Artigo em Inglês | LILACS | ID: biblio-887118
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Background:

The onset of vitiligo during childhood is common. Limited data exist that compare the clinical associations of prepubertal and postpubertal vitiligo in Arabs.

Objective:

To compare the clinical profile of pre and postpubertal onset vitiligo.

Methods:

A cross-sectional observational study was conducted. The Vitiligo European Task Force questionnaire was completed for each patient.

Results:

A total of 375 patients were included; 199 had postpubertal vitiligo (>12 years), and 176 had prepubertal onset vitiligo (<12years). There were more females in the prepubertal group (49%) than in the postpubertal group (29%), p-value <0.001. The prepubertal group has had more involvement than the postpubertal group (45% vs 30%, p=0.004). Only 8 cases of segmental vitiligo were observed; five were observed in the prepubertal group of patients. Female gender (OR=2.3; 95% CI1.5, 3.5), presence of halo nevus (OR=2.2; 95% CI1.1, 4.4) and face involvement (OR=1.9; 95% CI1.2, 2.9) were positively associated with prepubertal vitiligo. Stress, as an onset factor, was positively associated (OR=0.51; 95% CI0.3, 0.8) with postpubertal onset vitiligo. Study

limitations:

A possible selection bias toward more severe vitiligo cases can be a limitation, because the study was conducted in a clinic specialized in vitiligo. Moreover, a likelihood of false recall bias cannot be excluded.

Conclusions:

Our data present clinical evidence that vitiligo behaves mostly the same way in the prepubertal group as in the postpubertal group. However, female over-representation, more face involvement and more halo nevi were observed in prepubertal vitiligo, while stress was more prevalent as an aggravating factor in postpubertal vitiligo patients.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Vitiligo / Puberdade Tipo de estudo: Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Adolescente / Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: An. bras. dermatol Assunto da revista: Dermatologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Arábia Saudita Instituição/País de afiliação: King Saud University/SA

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Vitiligo / Puberdade Tipo de estudo: Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Adolescente / Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: An. bras. dermatol Assunto da revista: Dermatologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Arábia Saudita Instituição/País de afiliação: King Saud University/SA
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