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Breast cancer diagnosed before the 40 years: imaging findings and correlation with histology and molecular subtype
Eugênio, Deise Santiago Girão; Souza, Juliana Alves; Chojniak, Rubens; Bitencourt, Almir Galvão Vieira; Graziano, Luciana; Marques, Elvira Ferreira.
Afiliação
  • Eugênio, Deise Santiago Girão; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
  • Souza, Juliana Alves; A.C.Camargo Cancer Center. Imaging Department. Reseach Nursing. São Paulo. BR
  • Chojniak, Rubens; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
  • Bitencourt, Almir Galvão Vieira; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
  • Graziano, Luciana; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
  • Marques, Elvira Ferreira; A.C.Camargo Cancer Center. Imaging Department. São Paulo. BR
Appl. cancer res ; 37: 1-7, 2017. tab, ilus
Artigo em Inglês | LILACS, Inca | ID: biblio-911527
Biblioteca responsável: BR30.1
Localização: BR30.1
ABSTRACT

Background:

To evaluate the imaging findings in patients with breast cancer diagnosed before age 40 and their correlation with histological type and molecular subtype.

Methods:

A descriptive, retrospective, single-center study was conducted by reviewing imaging exams and medical records, after approval of the institution's Ethics Review Board. Among the 120 patients studied, 112 (93.3%) had mammography, 113 (94.2%) underwent ultrasonography and 105 (87.5%) underwent breast magnetic resonance imaging (MRI). Histopathology data was performed in most cases after surgical resection, which was available for 113 patients (94.2%).

Results:

The mean age at diagnosis of primary breast cancer was 34 years. Most patients had no family history of breast cancer or ovarian cancer (60.7%), and were symptomatic at diagnosis (75.6%). The most common histological type was no-special type (NST) invasive carcinoma (73.8%). Regarding the molecular subtype, luminal B was the most common (42.6%), followed by triple negative (20.2%). The malignant tumor was identified in 92.9% of patients who underwent mammography, 96.5% of patients submitted to ultrasound and 98% of those who performed MRI. MRI was superior to other methods in the evaluation of multifocal and multicentric lesions. There was no statistically significant association between imaging findings and molecular subtypes in the present study.

Conclusions:

This study demonstrated that imaging methods play a fundamental role in the characterization of cases of breast cancer diagnosed in patients younger than 40 years. Despite the ultrasound has been the most widely used method, we found improved characterization of breast lesions when also used mammography and MRI (AU)
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS / Inca Assunto principal: Neoplasias da Mama / Imagem por Ressonância Magnética / Mamografia / Ultrassonografia Mamária Limite: Humanos Idioma: Inglês Revista: Appl. cancer res Assunto da revista: Neoplasias Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: A.C.Camargo Cancer Center/BR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS / Inca Assunto principal: Neoplasias da Mama / Imagem por Ressonância Magnética / Mamografia / Ultrassonografia Mamária Limite: Humanos Idioma: Inglês Revista: Appl. cancer res Assunto da revista: Neoplasias Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: A.C.Camargo Cancer Center/BR
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