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Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling
Shi, Qingbin; Cai, Xiuying; Shi, Guixiang; Lv, Xingle; Yu, Jinping; Wang, Feng.
Afiliação
  • Shi, Qingbin; Traditional Chinese Medicine Hospital. Zhangqiu District. Department of Encephalopathy. CN
  • Cai, Xiuying; Traditional Chinese Medicine Hospital. Zhangqiu District. Department of Encephalopathy. CN
  • Shi, Guixiang; Traditional Chinese Medicine Hospital. Zhangqiu District. Department of Encephalopathy. CN
  • Lv, Xingle; Traditional Chinese Medicine Hospital. Zhangqiu District. Department of Encephalopathy. CN
  • Yu, Jinping; Traditional Chinese Medicine Hospital. Zhangqiu District. Department of Encephalopathy. CN
  • Wang, Feng; Traditional Chinese Medicine Hospital. Zhangqiu District. Department of Encephalopathy. CN
Acta cir. bras ; 33(6): 491-498, June 2018. graf
Artigo em Inglês | LILACS | ID: biblio-949359
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Purpose:

To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy.

Methods:

The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Vincristine induced increased sensitivity to mechanical stimulation was measured by von Frey hair test 7 and 14 days after intraperitoneal administration of 0.1 mg/kg vincristine in mice. Relative expression levels of cytokines were detected by quantitative real-time PCR. STAT6 expression following vincristine treatment was assessed with western blotting.

Results:

We discovered that IL-4/STAT6 signaling was down-regulated in vincristine-treated mice. Deletion of IL-4 in mice increased the sensitivity to mechanical allodynia. IL-4 knockout mice also produced more pro-inflammatory cytokines, including IL-1β and TNF-α. Notably, co-administration of exogenous recombination IL-4 significantly prevented vincristine-induced mechanical allodynia.

Conclusion:

Anti-inflammatory cytokine IL-4 protects rodent model from vincristine-induced peripheral neuropathy via the stimulation of IL-4/STAT6 signaling and inhibition of the pro-inflammatory cytokines.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Vincristina / Interleucina-4 / Doenças do Sistema Nervoso Periférico / Fator de Transcrição STAT6 / Anti-Inflamatórios / Antineoplásicos Fitogênicos Tipo de estudo: Estudo de avaliação / Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Traditional Chinese Medicine Hospital/CN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Vincristina / Interleucina-4 / Doenças do Sistema Nervoso Periférico / Fator de Transcrição STAT6 / Anti-Inflamatórios / Antineoplásicos Fitogênicos Tipo de estudo: Estudo de avaliação / Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Traditional Chinese Medicine Hospital/CN
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