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Effects of baicalin on inflammatory reaction, oxidative stress and PKDl and NF-kB protein expressions in rats with severe acute pancreatitis
Qian, Yunzhong; Chen, Yi; Wang, Linyang; Tou, Jinfa.
Afiliação
  • Qian, Yunzhong; Zhejiang University. School of Medicine. The Children's Hospital. Hangzhou. CN
  • Chen, Yi; Zhejiang University. School of Medicine. The Children's Hospital. Hangzhou. CN
  • Wang, Linyang; Zhejiang University. School of Medicine. The Children's Hospital. Hangzhou. CN
  • Tou, Jinfa; Zhejiang University. School of Medicine. The Children's Hospital. Hangzhou. CN
Acta cir. bras ; 33(7): 556-564, July 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-949368
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Purpose:

To investigate the effects of baicalin on inflammatory reaction, oxidative stress and protein kinase D1 (PKD1) and nuclear factor-kappa B (NF-κB) protein expressions in severe acute pancreatitis (SAP) rats.

Methods:

Sixty rats were divided into sham operation, model, and low-, medium- and high-dose baicalin group. SAP model was established in later 4 groups. The later 3 groups were injected with 0.1, 0.2 and 0.4 ml/100 g 5% baicalin injection, respectively. At 12 h, the serum SAP related indexes and inflammatory factors, peripheral blood CD3 and γδT cell percentages, wet/dry ratio and pancreas ascites volume, oxidative stress indexes and PKD1 and NF-κB protein expressions in pancreatic tissue were determined.

Results:

Compared with model group, in high-dose baicalin group the wet/dry ratio and ascites volume, serum amylase level, phospholipase A2 activity, TNF-α, IL-1 and IL-6 levels, and pancreatic malondialdehyde level and PKD1 and NF-κB protein expression were significantly decreased (P < 0.05), and peripheral blood CD3 and γδT cell percentages and pancreatic superoxide dismutase and glutathione peroxidase levels were significantly increased (P < 0.05).

Conclusion:

Baicalin can resist the inflammatory reaction and oxidative stress, and down-regulate protein kinase D1 and nuclear factor-kappa B protein expressions, thus exerting the protective effects on severe acute pancreatitis in rats.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Pancreatite / Flavonoides / Proteína Quinase C / Anti-Inflamatórios não Esteroides / NF-kappa B / Estresse Oxidativo Tipo de estudo: Estudo de avaliação / Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Zhejiang University/CN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Pancreatite / Flavonoides / Proteína Quinase C / Anti-Inflamatórios não Esteroides / NF-kappa B / Estresse Oxidativo Tipo de estudo: Estudo de avaliação / Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Zhejiang University/CN
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