Density of mast cells and intensity of pruritus in psoriasis vulgaris: a cross sectional study
An. bras. dermatol
; 93(3): 368-372, May-June 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-949901
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract BACKGROUND:
Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-to-control symptom. The mediators involved in psoriatic pruritus have not been fully established.OBJECTIVE:
To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus.METHODS:
29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit.RESULTS:
Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). STUDYLIMITATIONS:
The small sample size may be considered the main limitation of our study.CONCLUSIONS:
Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Prurido
/
Psoríase
/
Pele
/
Mastócitos
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Clinic of Dermatology Pargendler/BR
/
Universidade Federal do Rio Grande do Sul/BR