Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions
Braz. j. pharm. sci
; 52(4): 709-714, Oct.-Dec. 2016. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-951883
Biblioteca responsável:
BR40.1
Localização: BR40.1
ABSTRACT
ABSTRACT The Maillard reaction of hydrochlorothiazide (HCTZ) and lactose has been previously demonstrated in pharmaceutical formulations. In this study, the activation energy of - hydrohlorothiazide and lactose interaction in the liquid state was ascertained under basic and neutral conditions. Conventional isothermal High Performance Liquid Chromatography (HPLC) technique was employed to ascertain the kinetic parameters using Arrhenius method. Results:
The activation energy obtained was 82.43 and 100.28 kJ/mol under basic and neutral conditions, respectively. Consequently, it can be inferred that Maillard reaction is significantly affected by pH, which can be used as a control factor whenever the reaction potentially occurs.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Cinética
/
Hidroclorotiazida
/
Lactose
Idioma:
Inglês
Revista:
Braz. j. pharm. sci
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Irã
Instituição/País de afiliação:
Tabriz University of Medical Sciences/IR