Effects of cognitive-behavioral therapy on neurotrophic factors in patients with major depressive disorder
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 40(4): 361-366, Oct.-Dec. 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-959258
Biblioteca responsável:
BR1.1
ABSTRACT
Objective:
To correlate neurotrophic factors - brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and beta-nerve growth factor (beta-NGF) - and severity of depressive symptoms in patients diagnosed with major depressive disorder (MDD) undergoing cognitive-behavioral therapy (CBT).Methods:
In this quasi-experimental study, participants were selected by convenience and received 16 sessions of CBT. The outcomes of interest were severity of depressive symptoms and changes in neurotrophic factor levels after CBT. The differences between variables before and after treatment (deltas) were analyzed.Results:
Patients had significant changes in symptom severity after treatment. No significant associations were found between Beck Depression Inventory II (BDI-II) scores and any independent variable. No correlations were observed between BDNF or GDNF levels and BDI scores before or after treatment, although there was a trend toward significant differences in beta-NGF levels.Conclusion:
BDNF, beta-NGF, and GDNF were not influenced by the effects of CBT on depressive symptoms.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Terapia Cognitivo-Comportamental
/
Fator Neurotrófico Derivado do Encéfalo
/
Fator de Crescimento Neural
/
Transtorno Depressivo Maior
/
Fator Neurotrófico Derivado de Linhagem de Célula Glial
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Católica de Pelotas/BR