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Phenotype mapping of heart failure with preserved ejection fraction / Mapeamento fenotípico da insuficiência cardíaca com fração de ejeção preservada
Int. j. cardiovasc. sci. (Impr.) ; 31(6): 652-661, nov.- dez. 2018. tab, ilus
Artigo em Inglês | LILACS | ID: biblio-979988
Biblioteca responsável: BR44.1
Localização: BR44.1
ABSTRACT
Heart failure with preserved ejection fraction (HFPEF) has become the main phenotypic model of heart failure (HF) in community and referral patients in Brazil and in the world. Despite advances in the development of new drugs for HF treatment, there has been no significant improvement in mortality of this condition. According to many studies, this can be explained by the heterogeneous nature of HF physiopathology, whose basic mechanisms may result in different clinical presentations, culminating in the emerging of different phenogroups in this syndrome. In this context, phenotype mapping of HFPEF has emerged as a possible solution, since it enables the development of clinical trials that establish specific therapeutic strategies for each phenotypic profile. New technologies in the field of artificial intelligence have enabled the assessment of a large volume of data and infer intrinsic patterns and different outcomes. Thereby, it is possible to obtain mutually exclusive categories of HFPEF, with a phenotype mapping of the syndrome and grouping of patients according to their phenotypic features. Besides, other diseases can have the same clinical phenotype but different pathophysiological basis, the so called "phenocopies". These tools enable the analysis and categorization of the wide spectrum of heart failure, contributing to solve the dilemmas of the treatment of this syndrome
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Fenótipo / Volume Sistólico / Aprendizado de Máquina / Insuficiência Cardíaca Aspecto clínico: Diagnóstico / Etiologia Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Int. j. cardiovasc. sci. (Impr.) Assunto da revista: Cardiologia Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal Fluminense/BR