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Las alteraciones de la microbiota intestinal en la patogenia del hígado graso no alcohólico / Alterations of the intestinal microbiota in the pathogenesis of nonalcoholic fatty liver disease
Guíñez F, Dannette; Poniachik T, Jaime; Gotteland, Martín; Magne, Fabien; Urzúa M, Álvaro; Iracheta M, Alexis; Pérez de Arce O, Edith; Madrid S, Ana María; Videla C, Luis A; Vera P, Daniela; Beltrán M, Caroll J.
Afiliação
  • Guíñez F, Dannette; Hospital Clínico Universidad de Chile. Departamento de Medicina. Santiago. CL
  • Poniachik T, Jaime; Hospital Clínico Universidad de Chile. Servicio de Gastroenterología. Santiago. CL
  • Gotteland, Martín; Universidad de Chile. Facultad de Medicina. Departamento de Nutrición. Santiago. CL
  • Magne, Fabien; Universidad de Chile. Facultad de Medicina. Instituto de Ciencias Biomédicas. Programa de Microbiología y Micología. Santiago. CL
  • Urzúa M, Álvaro; Hospital Clínico Universidad de Chile. Servicio de Gastroenterología. Santiago. CL
  • Iracheta M, Alexis; Hospital Clínico Universidad de Chile. Servicio de Gastroenterología. Santiago. CL
  • Pérez de Arce O, Edith; Hospital Clínico Universidad de Chile. Servicio de Gastroenterología. Santiago. CL
  • Madrid S, Ana María; Hospital Clínico Universidad de Chile. Servicio de Gastroenterología. Santiago. CL
  • Videla C, Luis A; Universidad de Chile. Facultad de Medicina. Instituto de Ciencias Biomédicas. Programa de Farmacología Molecular y Clínica. Santiago. CL
  • Vera P, Daniela; Hospital Clínico Universidad de Chile. Servicio de Gastroenterología. Santiago. CL
  • Beltrán M, Caroll J; Hospital Clínico Universidad de Chile. Servicio de Gastroenterología. Laboratorio de Inmunogastroenterología. Santiago. CL
Rev. Hosp. Clin. Univ. Chile ; 29(2): 136-143, 2018.
Artigo em Espanhol | LILACS | ID: biblio-986675
Biblioteca responsável: CL36.1
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is currently considered in Chile and worldwide, as the main cause of cirrhosis and liver transplantation. It is therefore one of the main public health objectives for reducing its prevalence. In last years, it was suggested that the intestinal microbiota (IM) might contribute to the pathophysiology of NAFLD, as well as in the progression toward nonalcoholic steatohepatitis (NASH) and cirrhosis. It is known that changes in the composition of IM are associated with alterations in intestinal permeability and the production of inflammatory metabolites. These alterations are part of the pathophysiological mechanisms leading to the development of NASH. However studies on MI in patients with NAFLD and NASH in Chile are scarce. Through a research grant, recently awarded at the Hospital Clínico Universidad de Chile, we aim to confirm and characterize the intestinal dysbiosis associated with NAFLD in Chilean patients and to establish the relationship between the changes in microbial composition with the progression of liver damage. The description of these alterations represents an opportunity to explore new therapeutic approaches for future interventions. In effect, through the restoration of an intestinal microbial environment towards homeostasis in these patients, we expect to reverse or improve the progression of damage provoked by this disease. (AU)
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Disbiose / Hepatopatia Gordurosa não Alcoólica Idioma: Espanhol Revista: Rev. Hosp. Clin. Univ. Chile Assunto da revista: Medicina Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Hospital Clínico Universidad de Chile/CL

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Disbiose / Hepatopatia Gordurosa não Alcoólica Idioma: Espanhol Revista: Rev. Hosp. Clin. Univ. Chile Assunto da revista: Medicina Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Hospital Clínico Universidad de Chile/CL
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