Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice
Acta cir. bras
; 34(2): e201900205, 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-989052
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms.Methods:
Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1 Control; G2 L-NAME; G3 L-NAME + TDF; G4 L-NAME + BRL 37344; G5 L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystometry to evaluate non-voiding contractions (NVC), threshold pressure (TP), baseline pressure (BP), frequency of micturition (FM) and threshold volume (TV). Differences between the groups were analyzed with ANOVA followed by the Tukey test.Results:
NVC increased in G2 (4.33±2.58) in relation to G1 (1.50±0.55). NVC decreased in G3 (2.00±1.10), G4 (1.50±1.52) and G5 (2.00±1.26) compared to G2 (p<0.05). FM decreased in G3 (0.97±0.71), G4 (0.92±0.38) and G5 (1.05±0.44) compared to G2 (p<0.05). However, the combination of TDF and BRL37344 was not more effective at increasing NVC and improving FM than either drug alone. The five groups did not differ significantly with regard to TV.Conclusion:
The combination of BRL 37344 and TDF produced no measurable additive effect on reduction of OB symptoms.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
Base de dados:
LILACS
Assunto principal:
Etanolaminas
/
Bexiga Urinária Hiperativa
/
Agentes Urológicos
/
Tadalafila
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
UFC/BR
/
Universidade Federal do Ceará/BR