Proteases associated with Mycobacterium tuberculosis infection
Rev. patol. trop
; 48(1): 1-12, abr. 2019. tab
Artigo
em Inglês
| LILACS
| ID: biblio-996650
Biblioteca responsável:
BR15.1
ABSTRACT
Tuberculosis is a contagious infectious disease caused by Mycobacterium tuberculosis, an obligate intracellular bacterium that relies on infection and host-to-host transmission to survive. In a co-evolutionary process, the pathogen developed virulence mechanisms to evade the host's immune system and endure a number of factors, such as cellular stress. One of the strategies used by pathogens to succeed in causing infection is the production of proteases, which are enzymes that cleave peptide bonds between the amino acids in a protein. Proteases are widely distributed in nature and have different roles considered important to the bacteria's biological cycle. M. tuberculosis has several protease coding genes in its genome, many of which with unknown functions, but several with recognized roles in the infection process. This review presents the literature researched from 2014 to 2018 that addressed the roles of the proteases involved in M. tuberculosis infection
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Tuberculose
Base de dados:
LILACS
Assunto principal:
Tuberculose
/
Doenças Transmissíveis
Tipo de estudo:
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. patol. trop
Assunto da revista:
Medicina Tropical
/
Patologia
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Institute of Tropical Pathology and Public Health, Federal University of Goiás (UFG)/BR