Clinical outcome of patients with relapsed/refractory acute leukemia treated with FLAG-IDA regimen
Hematología (B. Aires)
; 13(2): 49-52, mayo-ago. 2009. tab, graf
Artigo
em Inglês
| BINACIS
| ID: bin-124594
Biblioteca responsável:
AR67.1
Localização: AR67.1
ABSTRACT
Background:
Patients with Refractory/Relapsed (RIR) acute leukemia (AL) have a poor prognosis.Objective:
We aimed to evaluate the chemotherapy regimen fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin (FLAG-IDA) in patients with RIR AL. Patients We studied 33 patients with R/R AL. Distribution of the AL subtype was myeloblastic n=17 (52%), lymphoblastic n=14 (42%),) and biphenotypic n=2 (6%).Results:
Complete remission (CR) was achieved in 15 cases (45.5%) and seven patients dead resulting in a mortality of 21.1%. In patients with hematological recovery the median time to neutrophils recovery (> 0.5 x 10º/1) was 24 days (range 10-38); platelet levels of more than 20 x 1Oº/l and 50 x 10º/1 were reached in a median time of 24 (range 17-44) and 27 days (range 18-51), respectively. After CR, five patients underwent allogeneic transplan- tation and 10 patients
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Coleções:
Bases de dados nacionais
/
Argentina
Base de dados:
BINACIS
Assunto principal:
Transplante
/
Leucemia
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Hematología (B. Aires)
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Privado Centro Médico de Córdoba/Argentina
/
ITMO Hospital Italiano/Argentina