Effect of tolazoline on xylazine induced hyperglycemia in rats

ABSTRACT

The present study was conducted on 40 albino rats to investigate the effect of the alpha adrenergic blocker "tolazoline" on the hyperglycemia and glucosurea experimentally induced by intramuscular injection of xylazine with a single dose of 16 mg/kg b. wt. in the tested rats. The estimated plasma glucose levels were 262.7 +/- 15.9 and 321.5 +/- 27.3 mg/dl at one and two hours following xylazine injection, respectively as compared with the levels [122.2 +/- 1.4 and 127.1 +/- 3.0] of non treated animals. Tolazoline [4 mg/kg b. wt. i. p.] completely antagonized the hyperglycemic effect induced by xylazine and the glucose level was significantly decreased to 114.3 +/- 9.9 and 107.1 +/- 4.8 mg/dl at one and two hours following xylazine injection, respectively as compared with xylazine treated group. Xylazine injection induced glucosurea and this effect can be antagonized by tolazoline injection. It is concluded that effect agent to counteract the tolazaective "an alpha [2] antagonist" is an hyperglycemic effect of xylazine. Moreover this study emphasis the role of alpha [2] receptors in regulation of blood glucose