Interaction of tranylcypromine with bezafibrate on some aspects of lipids metabolism, in rats

ABSTRACT

Total phospholipids, total cholesterol, free fatty acids [FFA] as well as triglycerides in both plasma and liver of male rats were estimated for assessment of lipid metabolism. Concurrent administration of tranylcypromine along with bezafibrate intensified the bezafibrate- induced reduction in plasma and live phospholipids at the end of the first week. Meanwhile, tranylcypromine completely abolished the hypocholesterolemic effect of bezafibrate after 7 and 14 days of their administration. On the other hand, the lowering effect of bezafibrate on plasma FFA was not affected by concomitant administration of tranylcypromine. However, hepatic FFA were markedly elevated in response to combined therapy, contrary to the reduction in their level in response to bezafibrate alone. In the meantime, the hypotriglyceridemic effect of bezafibrate was diminished by the end of 7 days and completely abolished by the end of 14-day treatment on concurrent administration of tranylcypromine