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[Anxiolytic effect of L-carnitine in adult male rats]
Qom University of Medical Sciences Journal. 2014; 8 (4): 1-5
em Persa Moderno | IMEMR | ID: emr-149798
Biblioteca responsável: EMRO
ABSTRACT
The beneficial effect of L-carnitine for treatment of neurological diseases has been investigated in various studies. The aim of the present study was to investigate the effect of L-carnitine supplement on anxiety behavior in adult male rats by elevated plus maze. In this experimental study, the studied groups were divided into normal, saline, and experimental groups. L-carnitine was administered intraperitoneally at doses of 0.5, 1, 2, and 4 mg/kg were, and saline control group received saline as vehicle. The data were analyzed using one-way ANOVA and Dunnett's test. The significance level was considered as p<0.05. In this study, the anxiolytic response of the drug was evaluated by elevated plus maze 30 minutes after treatment. L-carnitine treatment increase time spent in open arms, number of entries into open and dark arms or locomotor activity,%OAE, while decreased%OAT [p<0.01]. The results of this study indicated that L-carnitine has anxiolytic effect on male rats
Assuntos
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Base de dados: IMEMR Assunto principal: Ansiedade / Ratos / Ansiolíticos Limite: Animais Idioma: Persa Moderno Revista: Qom Univ. Med. Sci. J. Ano de publicação: 2014
Buscar no Google
Base de dados: IMEMR Assunto principal: Ansiedade / Ratos / Ansiolíticos Limite: Animais Idioma: Persa Moderno Revista: Qom Univ. Med. Sci. J. Ano de publicação: 2014
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