[Anxiolytic effect of L-carnitine in adult male rats]
Qom University of Medical Sciences Journal. 2014; 8 (4): 1-5
em Persa Moderno
| IMEMR
| ID: emr-149798
Biblioteca responsável:
EMRO
ABSTRACT
The beneficial effect of L-carnitine for treatment of neurological diseases has been investigated in various studies. The aim of the present study was to investigate the effect of L-carnitine supplement on anxiety behavior in adult male rats by elevated plus maze. In this experimental study, the studied groups were divided into normal, saline, and experimental groups. L-carnitine was administered intraperitoneally at doses of 0.5, 1, 2, and 4 mg/kg were, and saline control group received saline as vehicle. The data were analyzed using one-way ANOVA and Dunnett's test. The significance level was considered as p<0.05. In this study, the anxiolytic response of the drug was evaluated by elevated plus maze 30 minutes after treatment. L-carnitine treatment increase time spent in open arms, number of entries into open and dark arms or locomotor activity,%OAE, while decreased%OAT [p<0.01]. The results of this study indicated that L-carnitine has anxiolytic effect on male rats
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Base de dados:
IMEMR
Assunto principal:
Ansiedade
/
Ratos
/
Ansiolíticos
Limite:
Animais
Idioma:
Persa Moderno
Revista:
Qom Univ. Med. Sci. J.
Ano de publicação:
2014