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Involvement of nitric oxide system on anxiolytic-like behaviors induced by cholestasiss
Basic and Clinical Neuroscience. 2012; 3 (5): 19-29
em Inglês | IMEMR | ID: emr-155120
Biblioteca responsável: EMRO
ABSTRACT
The mechanisms of hepatic encephalopathy are not fully understood. Moreover, there is no comprehensive data concerning the effects of nitric oxide [NO] system on anxiolytic-like behaviors induced by bile duct ligation [BDL]. Male mice weighing 25-30 g were used and anxiety-like behaviors were tested using hole-board task. The data indicated that cholestasis increased the number of head-dipping but did not alter other aspects of behavior, 7 days after BDL, suggesting an anxiolytic-like response. Furthermore, the results showed that intraperitoneal [i.p.] injection of L-arginine [200 and 250 mg/kg] 15 min before testing induced anxiolytic-like behaviors in the normal animals, 4 and 7 days after BDL [considering that the dose of 200 mg in the normal mice is ineffective but is effective in the BDL mice]. On the other hand, injection of L-NAME [35 and 45 mg/kg, i.p.] 15 min before testing induced anxiogenic-like behaviors in the normal animals, 4 and 7 days after BDL [the dose of 35 mg/kg in the normal mice is ineffective but is effective in the BDL mice]. Moreover, injection of ineffective doses of L-NAME [25 and 35 mg/kg, i.p.] 15 min before administration of L-arginine [250 mg/kg, i.p.] and 7 days after BDL, decreased anxiolytic-like behaviors, significantly. Cholestatic mice show anxiolytic-like behaviors suggesting the involvement of the nitric oxide system
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Base de dados: IMEMR Idioma: Inglês Revista: Basic Clin. Neurosci. Ano de publicação: 2012
Buscar no Google
Base de dados: IMEMR Idioma: Inglês Revista: Basic Clin. Neurosci. Ano de publicação: 2012
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