1, 25 dihydroxyvitamin D3 protects the heart against pressure overload-induced hypertrophy without affecting SIRT1 mRNA level

ABSTRACT

Background and Aims: there has been scant information concerning antihypertrophic effects of vitamin D specifically on its cellular and molecular mechanisms. Sirtuin 1 [SIRT1] is regarded as a key deacetylase enzyme in cardiomyocytes which applies potential cardioprotective effects by functional regulation of different proteins. This study aimed to evaluate the effects of 1, 25-dihydroxyvitamin D on the hypertrophic markers and cardiac level of SIRT1 mRNA in rats following the aortic banding