Modulation of visfatin levels by thiazolidinediones in insulin resistant sprague dawley rats

ABSTRACT

Background: Insulin resistance is manifested by decreased effect of fixed quantity of insulin on glucose metabolism leading to type 2 diabetes mellitus. Visceral obesity has a positive correlation with insulin resistance but its mechanism is not fully defined. Insulin resistance may be the consequence of adipocytokines including visfatin and resistin. This study was designed to see the effect of thiazolidinediones on visfatin levels in insulin resistant rats