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Evening versus morning administration of statins [randomized clinical study]
Benha Medical Journal. 2004; 21 (3): 841-854
em Inglês | IMEMR | ID: emr-203491
Biblioteca responsável: EMRO
ABSTRACT
Cardiovascular disease is a leading cause of morbidity and mortality in the industrialised world. Observational studies have demonstrated a clear link between elevated serum low density lipoprotein [LDL] cholestrol concentrations and coronary heart disease, making hyperlipidaemia a significant modifiable risk factor that can be targted. Statins reduce cellular cholesterol synthesis and rapidly became popular for the primary and secondary prevention of coronary artery disease because they cause larger and clinically significant reductions in cholesterol levels, with few serious adverse effects, and are well tolerated by patients. Most manufacturers of statins recommend that they are taken at night, on the basis of physiological studies which show that most cholesterol is synthesized when dietary intake is at its lowest. Moreover, many patients also receive treatment with other cardioprotective drugs at night and compliance may be compromised by multiple dosing. The aim of this study was to determine wheather adminstration of atorvastatin in the morning had significant different efficacy from its adminstration in the evening. This study was done on forty patients of both sex of age range 44-72 years. Patients were randomised on either 10 or 20 mg/day of atorvasatin in the morning or in the evening for six weeks each. Neither sex nor daily doses variation [10 or 20 mg/day] produced significant changes in lipid profiles between baseline and follow up data in all groups. Switching dosing atorvastatin from in the morning to in the evening the resulted in statistically significant decrease in total cholesterol, LDL cholesterol and triglyceride and non-significant increase in HDL cholesterol value
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Base de dados: IMEMR Idioma: Inglês Revista: Benha Med. J. Ano de publicação: 2004
Buscar no Google
Base de dados: IMEMR Idioma: Inglês Revista: Benha Med. J. Ano de publicação: 2004
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