Epoxidation of some skin-photosensitizes and anticoagulants of natural coumarin and furocoumarins as potential alkylating agents of DNA

ABSTRACT

Epoxidation of khellin [I] by dimethyl-dioxirane [DMD] afforded the epoxide derivatives V and VI. Similarly, xanthotoxol [II] and 2-amino- methylpsoralen [III] were epoxidized with DMD to give the epoxide derivatives VII and VIII, respectively. Epoxidation of 4-hydroxycoumarin [IV] gave the epoxide derivative IX