N1, N3-diarly sulfonylureas as possible anticancer agents

ABSTRACT

This study described the synthesis of a number of sulofenur thiadiazole analogues with structural modification of the aryl moiety of the sulfonamide portion of the diaryl sulfonylureas. Two different methods were adopted in order to prepare the target compounds. The new compounds were evaluated for in vitro cytotoxic activity. Two compounds showed 100% activity against Ehrlich ascites tumor cells