Autologous bone marrow-derived stem cell therapy in patients with Buerger's disease
Endovascular Journal. 2009; 2 (1): 18-22
em Inglês
| IMEMR
| ID: emr-91060
Biblioteca responsável:
EMRO
ABSTRACT
Patients suffering from Thrornboangiitis Obliterans [TAO] or Buerger's disease have endothelial cell dysfunction and the severity of the disease lies in the need for amputation in more than a quarter of all sufferers. The aim of present study was to determine whether granulocyte colony-stimulating factor mobilized autologous bone-marrow derived mononuclear cells transplantation improves endothelial dysfunction in these patients. Circulating mononuclear cells containing endothelial progenitor cells were obtained from patients following bone-marrow mobilization with granulocyte colony stimulating factor. Mononuclear cells and CD34+ cells were enumerated prior to intramuscular injection into the affected limbs. In this pilot study, autologous bone-marrow derived mononuclear cell therapy collected from peripheral blood following granulocytes colony stimulating factor [G-CSF] mobilization was effective, safe and resulted in sustained clinical results for patients with severe peripheral occlusive arterial diseases
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Base de dados:
IMEMR
Assunto principal:
Tromboangiite Obliterante
/
Trombose
/
Transplante Autólogo
/
Medula Óssea
/
Fator Estimulador de Colônias de Granulócitos
/
Transplante de Células-Tronco
/
Células Endoteliais
/
Indutores da Angiogênese
/
Amputação Cirúrgica
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Endovascular J.
Ano de publicação:
2009